Portable Automatic Microring Resonator System Using a Subwavelength Grating Metamaterial Waveguide for High-Sensitivity Real-Time Optical-Biosensing Applications
Portable Automatic Microring Resonator System Using a Subwavelength Grating Metamaterial Waveguide for High-Sensitivity Real-Time Optical-Biosensing Applications
复制标题
DOI：
10.1109/tbme.2020.3029148
复制
发表时间：
2021-06-01
影响因子：
4.6
通讯作者：
Chen, Ray T.
中科院分区：
文献类型：
--
作者：
Soni, Varun;Chang, Ching-Wen;Chen, Ray T.
在过去的几十年中，慢光传感器技术已经被应用于生物相关的检测。然而，类似的测试系统太大而不能携带到偏远地区进行诊断或即时测试。本研究以微型共振器为基础，建立一套全自动的可携式生物感测系统。光纤阵列安装在基于控制器的微定位系统上，该微定位系统可以与MATLAB接口来定位光源和波导耦合对准的暂定位置。芯片适配器和微流体通道可以被包装为产品，使得其制造便宜并且可以在每次进行测试之后被丢弃。因此，该平台可以更容易地通过没有光子学专业知识的普通用户来操作。它是基于常规光通信波长范围设计的。C波段超发光二极管光源通过光栅耦合器技术耦合进/出微传感器获得准TE模。为了保持稳定的化学结合反应，开发了具有成本效益的微流体泵，通过使用伺服电机，Arduino板和电机驱动器提供20 μ L/min的特定流速。亚波长光栅超材料环形谐振器通过粘附在传感器上的生物标记物引起的表面折射率变化显示出高灵敏度的传感性能。实时峰移监测显示基于生物素-链霉亲和素结合反应的10 μ g/mL链霉亲和素检测限。通过在传感器表面固定不同的特异性受体，该系统可以应用于重金属检测、气体传感、病毒检测、癌症标志物诊断等开放性应用。
The slow light sensor techniques have been applied to bio-related detection in the past decades. However, similar testing-systems are too large to carry to a remote area for diagnosis or point-of-care testing. This study demonstrated a fully automatic portable biosensing system based on the microring resonator. An optical-fiber array mounted on a controller based micro-positioning system, which can be interfaced with MATLAB to locate a tentative position for light source and waveguide coupling alignment. Chip adapter and microfluidic channel could be packaged as a product such that it is cheap to be manufactured and can be disposed of after every test conducted. Thus, the platform can be more easily operated via an ordinary user without expertise in photonics. It is designed based on conventional optical communication wavelength range. The C-band superluminescent-light-emitting-diode light source couples in/out the microring sensor to obtain quasi-TE mode by grating coupler techniques. For keeping a stable chemical binding reaction, the cost-effective microfluidic pump was developed to offer a specific flow rate of 20 mu L/min by using a servo-motor, an Arduino board, and a motor driver. The subwavelength grating metamaterial ring resonator shows highly sensitive sensing performance via surface index changes due to biomarker adhered on the sensor. The real-time peak-shift monitoring shows 10 mu g/mL streptavidin detection of limit based on the biotin-streptavidin binding reaction. Through the different specific receptors immobilized on the sensor surface, the system can be utilized on the open applications such as heavy metal detection, gas sensing, virus examination, and cancer marker diagnosis.