Large B-cell lymphoma of the leg in a patient with multiple malignant tumours.
Large B-cell lymphoma of the leg in a patient with multiple malignant tumours.
复制标题
患有多种恶性肿瘤的患者腿部大 B 细胞淋巴瘤。
DOI：
10.1080/00015550310010612
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发表时间：
2003
影响因子：
3.6
通讯作者：
G. Kelényi
中科院分区：
文献类型：
--
作者：
N. Erős;Z. Károlyi;A. Kovács;A. Matolcsy;T. Barna;G. Kelényi
本文对1例既往有胃b细胞非霍奇金淋巴瘤、浸润性导管性乳腺癌和前额基底细胞癌的患者进行了研究。在对乳腺癌进行综合化疗和放疗三年后，患者左腿上出现了一个迅速扩大的溃疡性肿瘤。经组织病理学、免疫组织化学和免疫球蛋白基因重排分析确定为皮肤大b细胞淋巴瘤。没有发现皮肤外受累的迹象。尽管手术切除，干扰素- α 2b治疗和氯苯bucil +强的松化疗，在先前受影响的部位复发，因此患者接受放疗。她失去了随访，并在手术后约14个月死亡，未进行尸检。我们讨论了腿部大b细胞淋巴瘤的临床和组织学特征和预后，它与其他疾病的巧合，以及原发性多发性恶性肿瘤的罕见发生。
A patient who had primary gastric B-cell non-Hodgkin's lymphoma, invasive ductal breast cancer and a basocellular carcinoma of the forehead in her medical history was studied. Three years after polychemotherapy and irradiation of the breast cancer, a rapidly enlarging, ulcerated violaceous tumour developed on the patient's left leg. The tumour was identified by the histopathological, immunohistochemical and immunoglobulin gene rearrangement analyses as a cutaneous large B-cell lymphoma. No signs of extracutaneous involvement were detectable. Despite surgical excision, interferon-alpha2b treatment and chlorambucil + prednisone chemotherapy, a relapse occurred in the previously affected site, whereafter the patient received radiotherapy. She was lost to follow-up, and died approximately 14 months after the surgical intervention without autopsy. We discuss the clinical and histologic features and outcome of the large B-cell lymphoma of the leg, its coincidence with other diseases, and the uncommon occurrence of primary multiple malignant tumours.