Is the 5-HT1Dβ Receptor Gene Implicated in the Pathogenesis of Obsessive-Compulsive Disorder?
Is the 5-HT1Dβ Receptor Gene Implicated in the Pathogenesis of Obsessive-Compulsive Disorder?
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DOI：
10.1176/appi.ajp.157.7.1160
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发表时间：
2000-07
影响因子：
17.7
通讯作者：
E. Mundo;M. Richter;F. Sam;F. Macciardi;J. Kennedy
中科院分区：
文献类型：
--
作者：
E. Mundo;M. Richter;F. Sam;F. Macciardi;J. Kennedy
目的：强迫症（OCD）是一种精神疾病，有强有力的证据表明存在遗传成分和神经系统参与。最近的研究表明，舒马曲坦，5-羟色胺（5-HT）1Dβ自身受体的选择性配体，改善强迫症症状。为探讨5-HT 1D β受体基因与强迫症之间的连锁不平衡，对67例符合DSM-IV诊断标准的强迫症先证者及其父母或兄弟姐妹进行了DNA检测。结果：32个家系的遗传信息均为G等位基因。结论：5-HT 1D β受体基因可能是遗传性5-HT 1D β受体基因的重要组成部分。
OBJECTIVE: Obsessive-compulsive disorder (OCD) is a psychiatric condition for which strong evidence of a genetic component and serotonergic system involvement exists. Recent studies have shown that sumatriptan, a selective ligand of the serotonin (5-HT)1Dβ autoreceptor, modifies OCD symptoms. The aim of this study was to investigate the presence of linkage disequilibrium between the 5-HT1Dβ receptor gene, which has a variant caused by a silent G to C substitution at nucleotide 861 of the coding region, and OCD.METHOD: DNA was collected from 67 probands who met DSM-IV criteria for OCD and from their living parents or siblings. Transmission Disequilibrium Test/sib-Transmission Disequilibrium Test analyses were then conducted with the DNA data.RESULTS: Thirty-two families were informative for the analysis, which showed a preferential transmission of the G allele to the affected subjects.CONCLUSIONS: If the results are confirmed, there may be important implications for the 5-HT1Dβ receptor gene in the pathoge...