Targeting the Overexpressed YY1 in Cancer Inhibits EMT and Metastasis.
Targeting the Overexpressed YY1 in Cancer Inhibits EMT and Metastasis.
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DOI：
10.1615/critrevoncog.2017020473
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发表时间：
2017
影响因子：
--
通讯作者：
Bonavida B
中科院分区：
文献类型：
--
作者：
Cho AA;Bonavida B
最近在治疗各种癌症，特别是非转移性癌症方面取得了进展。然而，许多有反应的患者往往最初通过发展扩散的微小和巨大转移而复发。不幸的是，用于治疗转移性癌症的治疗方式非常少。已经提出癌症转移的发展涉及上皮-间充质转化（EMT），其中具有EMT表型的肿瘤细胞表现出各种表型标志物和分子修饰，这些表型标志物和分子修饰表现出抵抗大多数常规疗法。YY 1是癌症中过度活化的核因子-κ β途径的靶点，据报道，YY 1除了在EMT和抗性中的作用外，还调节细胞存活和细胞增殖。YY 1在大多数癌症中的过表达与不良预后相关。据推测，靶向YY 1可能导致几种抗肿瘤活性，包括抑制细胞存活和细胞增殖，抑制EMT和逆转耐药性。这篇综述讨论了潜在的治疗靶向的过表达的转录因子，阴阳1（YY 1），这已牵连在EMT和耐药性的发展。在实验模型中，针对YY 1的几个例子。
There have been recent developments in the treatment of various cancers, in particular non-metastatic cancers. However, many of the responding patients often relapse initially through the development of spread micro-and macro-metastases. Unfortunately, there are very few therapeutic modalities for the treatment of metastatic cancers. The development of cancer metastasis has been proposed to involve the epithelial–mesenchymal transition (EMT), in which the tumor cells with the EMT phenotype exhibit various phenotypic markers and molecular modifications that are manifested to resist most conventional therapies. YY1 is a target of the hyperactivated nuclear factor-kappa beta pathway in cancer and it was reported that YY1 also regulates cell survival and cell proliferation in addition to its role in EMT and resistance. The overexpression of YY1 in the majority of cancers has been correlated with poor prognosis. It is hypothesized that targeting YY1 may result in several anti-tumor activities, including inhibition of cell survival and cell proliferation, inhibition of EMT, and reversal of resistance. This review discusses the potential therapeutic targeting of an overexpressed transcription factor, Yin Yang 1 (YY1), which has been implicated in the development of EMT and drug resistance. Several examples targeting YY1 in experimental models are presented.