Cytokines as regulators of atherosclerosis in murine models.
Cytokines as regulators of atherosclerosis in murine models.
复制标题
细胞因子作为小鼠模型中动脉粥样硬化的调节剂。
DOI：
10.2174/138945007783220588
复制
发表时间：
2007
影响因子：
3.2
通讯作者：
A. Tedgui
中科院分区：
文献类型：
--
作者：
Z. Mallat;A. Tedgui
Atherosclerosis is a chronic inflammatory disease of the arterial wall initiated by a variety of pro-atherogenic stimuli, such as modified epitopes of phospholipids. Both innate and adaptive immune responses contribute to disease initiation and progression. Here, we review the major cytokines involved in this immuno-inflammatory response, and shown to significantly impact disease initiation and/or progression in murine models. We particularly emphasize the role of the regulatory arm of the immune response in disease modulation, and review the major factors that may be involved in its promotion or alteration.
