Pneumocystis jirovecii colonisation in patients with interstitial lung disease
Pneumocystis jirovecii colonisation in patients with interstitial lung disease
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DOI：
10.1111/j.1469-0691.2005.01337.x
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发表时间：
2006-03-01
影响因子：
14.2
通讯作者：
Calder贸n, EJ
中科院分区：
文献类型：
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作者：
Vidal, S;de la Horra, C;Calder贸n, EJ
进行了一项前瞻性研究，以确定80例疑似间质性肺病（ILD）后需要支气管镜检查和支气管肺泡灌洗（BAL）的连续患者中肺孢子虫定植的患病率。采用巢式PCR方法对支气管肺泡灌洗液中的耶洛氏疟原虫mtLSU rRNA基因进行了鉴定。ILD患者分为三组：A组包括特发性间质性肺炎患者; B组包括结节病患者; C组包括其他ILD患者。卡氏疟原虫携带的总体患病率为33.8%，A、B和C组的定植率分别为37.8%、18.8%和37%（p不显著）。携带者中吸烟者多于非携带者，但携带者与非携带者之间无其他显著差异。在西班牙免疫功能正常的ILD患者中发现的卡氏疟原虫携带者的高患病率表明卡氏疟原虫在这些疾病的自然史中可能发挥作用。
A prospective study was conducted to determine the prevalence of colonisation by Pneumocystis jirovecii in 80 consecutive patients who required bronchoscopy and bronchoalveolar lavage (BAL) following suspicion of interstitial lung disease (ILD). The mtLSU rRNA gene of P. jirovecii was identified by nested PCR in BAL samples. Patients with ILDs were divided into three groups: group A comprised those with idiopathic interstitial pneumonias; group B comprised those with sarcoidosis; and group C comprised those with other ILDs. The overall prevalence of P. jirovecii carriage was 33.8%, with colonisation rates of 37.8%, 18.8% and 37% in groups A, B and C, respectively (p not significant). There were more smokers among the carriers, but there were no other significant differences between carriers and non-carriers. The high prevalence of P. jirovecii carriers found among immunocompetent patients with ILDs in Spain suggests a possible role of P. jirovecii in the natural history of these diseases.