CELL THERAPY FOR MEDICATION-RELATED OSTEONECROSIS OF THE JAW: UPDATE ON TREATMENT STRATEGIES
CELL THERAPY FOR MEDICATION-RELATED OSTEONECROSIS OF THE JAW: UPDATE ON TREATMENT STRATEGIES
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DOI：
10.22203/ecm.v041a03
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发表时间：
2021-01-01
影响因子：
3.1
通讯作者：
Yamato, M.
中科院分区：
文献类型：
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作者：
Kaibuchi, N.;Iwata, T.;Yamato, M.
尽管自2003年首次报道药物相关性颌骨骨坏死（MRONJ）以来进行了广泛的研究，但该疾病的最佳治疗和预防方式尚不清楚。因此，它的管理一直是牙科、口腔和颌面外科以及世界范围内涉及癌症和/或骨病治疗的部门关注的问题。根据各种立场文件的建议，一些MRONJ病例无法通过常规治疗策略治愈。因此，许多研究，包括随机对照试验，已经进行了检验新疗法的疗效。然而，目前还没有确定的治疗方式。几种类型的细胞疗法已被记录在案。已有10项动物研究和5例病例报告，在MRONJ患者中进行了自体细胞移植。虽然这些报告显示了细胞疗法的疗效，但它们并不是大规模的、统计上准确的临床研究；因此，细胞疗法对这种疾病的疗效尚不确定。然而，自2013年以来，使用间充质基质细胞（MSC）片治疗MRONJ的疗效一直在研究中。通过将MSC薄片移植到模型大鼠和显示mronj样病变的比格犬的各种实验证实了这一点。基于这些结果，目前正在计划使用牙周韧带来源的MSC薄片进行MRONJ治疗的临床研究。
Despite extensive research since the first report of medication-related osteonecrosis of the jaw (MRONJ) in 2003, the optimal treatment and preventive modalities for the condition are not clear. Therefore, its management has been a concern in dentistry, oral and maxillofacial surgery, as well as departments involved in the treatment of cancers and/or bone diseases worldwide. Several cases of MRONJ could not be cured by conventional treatment strategies, as per the recommendations in various position papers. Therefore, a number of studies, including randomized controlled trials, have been conducted to examine the efficacy of novel therapies. However, no definite treatment modality has been determined. Several types of cell therapies have been documented. 10 animal studies and 5 case reports have been documented, in which autologous transplantation of cells has been carried out in MRONJ patients. Although these reports showed the efficacy of cell therapy, they were not large-scale, statistically accurate clinical studies; hence, the efficacy of cell therapy for this condition is not certain. However, the efficacy of MRONJ treatment using mesenchymal stromal cell (MSC) sheets has been investigated since 2013. This has been confirmed through various experiments in which MSC sheets were transplanted into model rats and beagle dogs exhibiting MRONJ-like lesions. Based on these results, a clinical study of MRONJ treatment using periodontal ligament-derived MSC sheets is being currently planned.