TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells
TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells
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DOI：
10.1016/j.bmcl.2003.11.043
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发表时间：
2004-02-09
影响因子：
2.7
通讯作者：
Hirama, M
中科院分区：
文献类型：
--
作者：
Inoue, M;Zhai, HF;Hirama, M
TMC-95 A已被表征为有效的蛋白酶体抑制剂，其在低纳摩尔浓度下与酶非共价结合。本文首次报道了TMC-95 A在PC 12大鼠嗜铬细胞瘤细胞中的神经突生成活性。TMC-95 A在1 - 20 μ M的浓度范围内诱导PC 12细胞的阳性神经突起始。(C)2003 Elsevier Ltd.保留所有权利。
TMC-95A has been characterized as a potent proteasome inhibitor that binds to enzymes non-covalently at low nanomolar concentrations. Herein, the neuritogenic activity of TMC-95A in PC12 rat pheochromocytoma cells is reported for the first time. TMC-95A induced a positive neurite initiation of PC12 cells at concentration ranging from 1 to 20 muM. (C) 2003 Elsevier Ltd. All rights reserved.