Are Anal Sex Roles Associated with Preferences for Pre-Exposure Prophylaxis Administration Modalities Among Men Who Have Sex with Men?
Are Anal Sex Roles Associated with Preferences for Pre-Exposure Prophylaxis Administration Modalities Among Men Who Have Sex with Men?
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DOI：
10.1007/s10508-017-1083-5
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发表时间：
2018-10-01
影响因子：
3.8
通讯作者：
Duncan, Dustin T.
中科院分区：
文献类型：
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作者：
Goedel, William C.;Schneider, John A.;Duncan, Dustin T.
目前的研究试图在法国巴黎的男男性行为者(MSM)样本中检查对现有的和理论上的HIV暴露前预防(PrEP)给药模式的认识、意愿和偏好，以及肛交角色与这些概念的关联。广播广告被放置在MSM流行的地理社交网络智能手机应用程序上，以指导用户完成基于网络的调查。MSM回答了有关他们最近参与无套肛交以及对使用PrEP的认识和意愿的问题，这些形式包括每日一次和事件驱动的药片方案、长效注射、阴茎和直肠杀菌剂以及性角色。多项回归模型适合于评估行为分类的肛门性角色与其中一种生物医学预防方式的偏好之间的关联。共有482名未感染艾滋病毒的男男性接触者完成了这项调查，其中48.1%的人在之前的3个月内进行了某种形式的无套肛交。大多数受访者(85.3%)听说过每天一次的PrEP，但听说过其他预防策略的受访者较少。假设效果相同，长效注射是最常见的首选(21.8%)。行为定义为“底部”和“多功能”的MSM更倾向于长效注射(32.9%的“底部”和25.3%的“多功能”)。开发提供抗逆转录病毒药物和局部杀微生物剂的长效注射可能会为男男性接触者中的艾滋病毒预防提供更方便和可接受的选择，因为该样本中的男男性接触者愿意使用它们，并更愿意使用它们而不是目前可用的避孕药方案。
The current study sought to examine awareness of, willingness to use, and preferences for available and theoretical administration modalities for HIV pre-exposure prophylaxis (PrEP) and the association of anal sex roles with these concepts among a sample of men who have sex with men (MSM) in Paris, France. Broadcast advertisements were placed on a popular geosocial-networking smartphone application for MSM to direct users to complete a Web-based survey. MSM answered questions on their recent engagement in condomless anal intercourse and awareness of and willingness to use PrEP in the form of once daily and event-driven pill regimens, long-acting injections, and penile and rectal microbicides as well as sexual roles. Multinomial regression models were fit to assess the association between behaviorally classified anal sexual role and preferences for one of these biomedical prevention modalities. A total of 482 HIV-uninfected MSM completed the survey, 48.1% of whom engaged in some form of condomless anal intercourse in the preceding 3 months. Most respondents (85.3%) had heard of once daily PrEP, but fewer respondents had heard of other prevention strategies. Assuming equal effectiveness, long-acting injections were the most commonly preferred (21.8%). Behaviorally defined "bottom" and "versatile" MSM more frequently preferred long-acting injections (32.9% of "bottoms" and 25.3% of "versatiles"). The development of long-acting injections to deliver antiretroviral drugs and topical microbicides may offer more convenient and acceptable options for HIV prevention among MSM, as MSM in this sample were willing to use them and would prefer to use them over currently available pill regimens.