Cancer survivorship research: Challenge and opportunity
Cancer survivorship research: Challenge and opportunity
复制标题
DOI：
10.1093/jn/132.11.3494s
复制
发表时间：
2002-11-01
影响因子：
4.2
通讯作者：
Aziz, NM
中科院分区：
文献类型：
--
作者：
Aziz, NM
随着癌症早期检测和有效治疗策略的不断进步，以及人口老龄化，预计癌症诊断后的寿命将继续增加。本文回顾了目前癌症幸存者的患病率数据；讨论定义问题；将癌症生存作为一个科学研究领域；概述幸存者经历的癌症诊断和治疗的医疗和心理社会后遗症、知识差距和新出现的研究重点；探讨体重、营养和身体活动作为可能影响癌症生理或心理后遗症及其治疗的关键变量的作用；并讨论了癌症生存研究的发展模式。一个庞大且不断增长的癌症幸存者群体是过去三十年癌症研究的主要成就之一。生存的长度和质量都是重要的终点。许多癌症幸存者面临癌症治疗的后期和长期生理和社会心理影响，并可能导致过早死亡和发病。干预措施——治疗和生活方式——具有治疗或改善这些晚期影响的潜力，如果发现有效，必须加以开发、检查和传播。饮食、体重和身体活动干预措施在改善癌症及其治疗的多重不良后遗症方面具有相当大的希望，应在更多的癌症幸存者、长期幸存者、癌症部位研究不足的人群、少数民族文化群体或医疗服务不足的群体中进行调查。
With continued advances in strategies to detect cancer early and treat it effectively along with the aging of the population, the number of individuals living years beyond a cancer diagnosis can be expected to continue to increase. This paper reviews current prevalence data for cancer survivors; discusses definitional issues; examines cancer survivorship as a scientific research area; provides an overview of medical and psychosocial sequelae of cancer diagnosis and treatment experienced by survivors, gaps in knowledge and emerging research priorities; explores the role of weight, nutrition and physical activity as key variables carrying the potential to affect physiologic or psychosocial sequelae of cancer and its treatment; and discusses the evolving paradigm of cancer survivorship research. A large and growing community of cancer survivors is one of the major achievements of cancer research over the past three decades. Both length and quality of survival are important end points. Many cancer survivors are at risk for and develop physiologic and psychosocial late and long-term effects of cancer treatment that may lead to premature mortality and morbidity. Interventions-therapeutic and lifestyle-carry the potential to treat or ameliorate these late effects and must be developed, examined and disseminated if found effective. Diet, weight and physical activity interventions hold considerable promise for ameliorating multiple adverse sequelae of cancer and its treatment and should be investigated in larger populations of cancer survivors, those who are long-term survivors, those with understudied cancer sites and ethnocultural minority or medically underserved groups.