Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology
Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology
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DOI：
10.1016/j.fertnstert.2010.11.044
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发表时间：
2011-04-01
影响因子：
6.7
通讯作者：
Lane, Michelle
中科院分区：
文献类型：
--
作者：
Bakos, Hassan W.;Henshaw, Richard C.;Lane, Michelle
目的：探讨辅助生殖技术（ART）后父亲体重指数（BMI）与胚胎发育、妊娠及活产结局的关系。设计：ART周期的回顾性分析。单位：主要辅助生殖中心。病人：350对夫妇在一家私人生育诊所接受抗逆转录病毒治疗。干预措施：本研究未对患者进行干预。主要结局指标：活产结局和临床妊娠率。结果：父亲体重指数与早期胚胎发育无显著关系。然而，父亲体重指数的增加与囊胚发育、临床妊娠率和活产结果的降低有关。结论：据我们所知，这是第一个将父亲BMI增加与ART治疗后临床妊娠和活产率联系起来的报告。需要进一步的工作来阐明所涉及的机制。[j] .中国农业科学（英文版），2011;35(5):397 - 397。(C)2011年美国生殖医学学会。)
Objective: To determine the relationship between paternal body mass index (BMI), embryo development and pregnancy, and live birth outcomes after assisted reproductive technology (ART).Design: Retrospective analysis of ART cycles.Setting: Major assisted reproduction center.Patient(s): Three hundred five couples undergoing ART in a private fertility clinic.Intervention(s): No intervention was undertaken in patients involved in this study.Main Outcome Measure(s): Live birth outcomes and clinical pregnancy rates.Result(s): No significant relationship between paternal BMI and early embryo development was found. However, increased paternal BMI was associated with decreased blastocyst development, clinical pregnancy rates and live birth outcomes.Conclusion(s): To our knowledge, this is the first report linking increased paternal BMI and clinical pregnancy and live birth rates after ART treatment. Further work to elucidate the mechanisms involved is required. (Fertil Steril (R) 2011;95:1700-4. (C)2011 by American Society for Reproductive Medicine.)