Independent interaction of alprazolam and caffeine under chronic dose regimens on differential reinforcement of low-rate (DRL 45-s) performance.
Independent interaction of alprazolam and caffeine under chronic dose regimens on differential reinforcement of low-rate (DRL 45-s) performance.
复制标题
慢性剂量方案下阿普唑仑和咖啡因对低速（DRL 45-s）表现差异强化的独立相互作用。
DOI：
10.1007/s002130050450
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发表时间：
1997
影响因子：
3.4
通讯作者：
Falk,JL
中科院分区：
文献类型：
--
作者：
Lau,CE;Wang,Y;Falk,JL
在之前的研究中，我们发现阿普唑仑和咖啡因在急性剂量方案下的大鼠中存在独立的相互作用，使用两种测量方法（强化率和较短反应率）在3小时的疗程中对低率表现（DRL 45-s）进行差异强化。应用相同的行为终点，本研究调查了慢性剂量方案下阿普唑仑-咖啡因的相互作用。这两种药物都是口服的。急性阿普唑仑和咖啡因的剂量反应曲线（DRCs）被表征，然后用于确定各自慢性剂量方案的维持剂量。两种药物都以剂量相关的方式降低了强化率并增加了短期反应率。在慢性咖啡因、慢性阿普唑仑和同时服用慢性咖啡因-阿普唑仑的方案中，也测定了阿普唑仑的DRC。第二天观察到对咖啡因诱导的速率变化完全耐受。不完全耐受仅发生在较高剂量的阿普唑仑（7-12.5 mg/kg）。阿普唑仑和咖啡因之间没有交叉耐受性。停药后，表现逐渐恢复到基线水平。四种阿普唑仑DRCs以及作用时间曲线表明，在慢性剂量方案下，咖啡因既没有改变阿普唑仑效应的大小，也没有改变阿普唑仑效应的模式。Pöch DRC法进一步证实了阿普唑仑与咖啡因的独立相互作用。因此，尽管在急性和慢性剂量方案中产生了耐受性，但相互作用的独立性仍然适用于后者。
In previous research, we found an independent interaction of alprazolam and caffeine in rats under acute dose regimens using two measures (reinforcement rate and shorter-response rate) of a differential reinforcement of low rate performance (DRL 45-s) in 3-h sessions. Applying the same behavioral endpoints, the present study investigated the alprazolam-caffeine interaction under chronic dose regimens. Both drugs were administered by the oral route. Acute alprazolam and caffeine dose-response curves (DRCs) were characterized and were then used to determine the maintenance dose for the respective chronic dose regimens. Both drugs decreased the reinforcement rate and increased the shorter-response rate in a dose-related fashion. An alprazolam DRC also was determined during chronic-caffeine, chronic-alprazolam, and concurrent chronic-caffeine-alprazolam dose regimens. Complete tolerance to caffeine-induced rate changes was observed on the second day. Incomplete tolerance occurred only at higher alprazolam doses (7–12.5 mg/kg). Cross tolerance was not found between alprazolam and caffeine. Upon discontinuation of both drugs, performance progressively returned to baseline. The four alprazolam DRCs as well as the effect-time profiles demonstrated that caffeine altered neither the magnitudes nor the patterns of alprazolam effects on the two rates under chronic dose regimens. The Pöch DRC method further confirmed the independent interaction of alprazolam and caffeine. Thus, the independence of the interaction held for both the acute and chronic dose regimens despite the development of tolerance in the latter regimens.