Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats
Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats
复制标题
DOI：
10.1016/s0893-133x(01)00281-0
复制
发表时间：
2001-11-01
影响因子：
7.6
通讯作者：
White, FJ
中科院分区：
文献类型：
--
作者：
Brandon, CL;Marinelli, M;White, FJ
在学龄儿童中，使用精神刺激剂哌醋甲酯(MP)治疗注意缺陷多动障碍的人数急剧增加。我们测试了青春期大鼠反复暴露于中等剂量的MP(5和10 mg/kg ip 5或7天)是否增加了成年后对可卡因挑战的运动反应(行走和站立)。我们后来测试了重复暴露于低剂量MP(2 mg/kg ip，连续7天)是否增强了可卡因的精神运动效应，通过不同的激发剂量(0-30 mg/kg)测量，以及通过自身注射小剂量(75 mg/kg，iv)来测量可卡因的增强效应。我们发现，暴露在中等剂量的MP中会增强对可卡因的精神运动反应，但暴露在低剂量下只会增加可卡因的自我给药。这些结果表明，青春期大鼠暴露于低剂量MP可能会增加低增强剂的激励价值，从而使成年大鼠更容易受到可卡因自我给药的影响。(C)2001年美国神经精神药理学学院。爱思唯尔科学公司出版。
Treatment of attention deficit hyperactivity disorder with the psychostimulant drug methylphenidate (MP) has increased dramatically among schoolchildren. We tested whether repeated exposure to moderate doses of MP (5 and 10 mg/kg IP for 5 or 7 days) in adolescent rats increased reactivity to cocaine measured by motor responses (ambulations and rearing) to a cocaine challenge in adulthood. We later tested whether repeated exposure to a low dose of MP (2 mg/kg IP for 7 days) enhanced the psychomotor effects of cocaine, measured by different challenge doses (0-30 mg/kg) as well as to the reinforcing effects of cocaine, measured by self-administration of low-dose infusion (75 mug/kg, IV). We found that exposure to moderate doses of MP enhanced psychomotor responses to cocaine but exposure to a low dose only increased cocaine self-administration. These results suggest that adolescent exposure to low doses of MP in rats may increase the incentive value of low reinforcers, thereby rendering adult rats more susceptible to cocaine self-administration. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.