Perceptual hyperreactivity to auditory stimuli in patients with irritable bowel syndrome.
Perceptual hyperreactivity to auditory stimuli in patients with irritable bowel syndrome.
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DOI：
10.1080/003655200750023534
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发表时间：
2000
影响因子：
1.9
通讯作者：
S. Blomhoff;Morten Jacobsen;S. Spetalen;A. Dahm;U. Malt
中科院分区：
文献类型：
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作者：
S. Blomhoff;Morten Jacobsen;S. Spetalen;A. Dahm;U. Malt
背景肠易激综合征（IBS）患者对内脏刺激的感知异常;然而，迄今为止还没有研究调查IBS患者对非内脏刺激的感知。在本研究中，我们使用事件相关电位（ERP）来研究IBS患者是否与健康对照组在听觉刺激的处理上不同，如果是这样，这是如何受到情绪的影响。方法：我们比较了40例无精神疾病的女性肠易激综合征患者和20例健康对照者的听觉刺激事件相关电位。音调被用作标准和目标刺激，而带有情感内容的单词则被用作干扰物。第一个负波（N100）和平均振幅在50毫秒的时间间隔150和600毫秒之间的特征进行了评估。结果：在额中线电极，IBS患者对所有刺激的N100振幅均显著增强，在调整年龄、当前情绪和人格特征后仍持续存在。此外，刺激后200-300毫秒和400-500毫秒的波增强。后一种差异在调整情绪和人格特征后消失。结论：在额叶脑区，IBS患者似乎有一个高反应性的听觉刺激相比，对照组。刺激加工的后期成分（P300，N400）受情绪和人格特质的影响。这些可能有助于由应激引起的肠道运动的变化。这项研究表明，异常的大脑功能可能是肠易激综合征的一个因素。这可能阐明了一种脑-肠相互作用的机制，通过这种机制，心理社会应激可能影响患有肠动力障碍的非精神病受试者的内脏疼痛感知，以及精神病治疗对IBS症状的疗效。
BACKGROUND Patients with irritable bowel syndrome (IBS) have abnormal perception of visceral stimuli; however, no study has so far investigated the perception of non-visceral stimuli in IBS. In the present study we used event-related potentials (ERP) to study whether IBS patients differed from healthy controls in processing of auditory stimuli and, if so, how this was influenced by emotions. METHODS We compared ERPs to auditory stimuli in 40 female diarrhoea-predominant IBS patients without current psychiatric illness with those in 20 healthy controls. Tones were used as standard and target stimuli, and words with emotional content as distractors. Characteristics of the first negative wave (N100) and mean amplitudes in 50-msec time intervals between 150 and 600 msec were assessed. RESULTS At the frontal midline electrode IBS patients had significantly enhanced N100 amplitude to all stimuli, persisting after adjustment for age, current emotions, and personality traits. They additionally had enhanced waves 200-300 msec and 400-500 msec after stimulus. The latter differences disappeared after adjustment for emotions and personality traits. CONCLUSIONS In the frontal brain region, IBS patients seem to have a hyperreactivity to auditory stimuli compared with controls. Later elements (P300, N400) of stimulus processing were influenced by emotions and personality traits. These may possibly contribute to changes in intestinal motility caused by stress. The study indicates that aberrant brain functioning may be an element of the irritable bowel syndrome. It may elucidate a mechanism for brain-gut interaction by which psychosocial stress may influence visceral pain perception in non-psychiatric subjects with an intestinal motility disorder and also the efficacy of psychiatric treatment on IBS symptoms.