Potential determinants of T helper 2 markers and their distribution in school-aged children
Potential determinants of T helper 2 markers and their distribution in school-aged children
复制标题
辅助 T 2 标记的潜在决定因素及其在学龄儿童中的分布
DOI：
10.1016/j.alit.2022.07.009
复制
发表时间：
2023
影响因子：
6.8
通讯作者：
Konno Satoshi
中科院分区：
文献类型：
--
作者：
Goudarzi Houman;Ikeda-Araki Atsuko;Bamai Yu Ait;Ito Sachiko;Inao Tasuku;Yokota Isao;Miyashita Chihiro;Kishi Reiko;Konno Satoshi
背景：在成人人群中，关于辅助性T细胞2(Th2)生物标志物决定因素的数据越来越多。然而，这些生物标志物的决定因素和典型范围在一般儿童人群中还没有得到很好的研究。因此，我们评估了3个Th2生物标志物的决定因素和典型范围，包括血嗜酸性粒细胞、FeNO和血清总IgE。方法：我们使用多变量Logistic回归分析(n=428)检验与Th2生物标志物相关的出生前和出生后因素(n=428)，并使用逆概率加权将结果扩展到原始队列(n=17,009)。我们还测量了所有接受检查的儿童和没有过敏性疾病的健康参与者(n=180)的典型Th2生物标志物分布。结果：在9-11岁时，喘息(优势比(OR)7.63)、鼻炎(OR 3.14)和湿疹(OR 2.46)与血液中嗜酸粒细胞的增加显著相关。三种过敏性疾病均与FeNO和血清总IgE有关，但OR值均小于血嗜酸性粒细胞。二手烟与血嗜酸性粒细胞呈负相关(OR，0.38)。在最初的队列中也发现了类似的结果。男性性别和产前因素(母亲吸烟和父母过敏史)不是Th2水平升高的独立预测因素。结论：除喘息和鼻炎外，湿疹和二手烟暴露是儿童Th2生物标志物解释的独立因素。此外，成人血嗜酸性粒细胞的典型数值和分界值可能不适用于儿童。
Background: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 biomarkers, including blood eosinophils, FeNO, and serum total IgE in 9-11-year-old children in a prospective birth cohort.Methods: We examined the pre-and postnatal factors associated with Th2 biomarkers using multivariable logistic regression analysis (n= 428) and extended the results to the original cohort (n= 17,009) using inverse probability weighting. We also measured typical Th2 biomarker distribution in all examined children and healthy participants without allergic diseases (n= 180).Results: At age 9-11, wheeze (odds ratio (OR) 7.63), rhinitis (OR 3.14), and eczema (OR 2.46) were significantly associated with increased blood eosinophils. All three allergic conditions were associated with FeNO and total serum IgE, but the ORs were smaller than those for blood eosinophils. Secondhand smoking was inversely associated with the blood eosinophils (OR, 0.38). Similar results were found in the original cohort. Male sex and prenatal factors (maternal smoking and parental history of allergies) were not independent predictors of high Th2 levels.Conclusions: In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are independent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be applicable to children.