Cortical Morphology in 6-to 10-Year Old Children With Autistic Traits: A Population-Based Neuroimaging Study
Cortical Morphology in 6-to 10-Year Old Children With Autistic Traits: A Population-Based Neuroimaging Study
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DOI：
10.1176/appi.ajp.2014.14040482
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发表时间：
2015-05-01
影响因子：
17.7
通讯作者：
White, Tonya
中科院分区：
文献类型：
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作者：
Blanken, Laura M. E.;Mous, Sabine E.;White, Tonya
目的：最近的证据表明，自闭症谱系障碍（ASD）的社会障碍症状形成了一个扩展到普通人群的频谱。然而，目前尚不清楚ASD的神经解剖学是否在一般人群中也显示出类似的连续性。因此，本研究的山羊是调查皮质形态和自闭症特征之间的关系沿着一个连续的一个大的人口为基础的样本的幼儿。方法：本研究包括717名儿童，年龄在6-10岁，谁是参与者的一代R研究，一个大的人口为基础的队列。当孩子们大约6岁时，使用社会反应量表测量自闭症特征。获得高分辨率的MRI，和皮质的形态学措施，包括皮质厚度和gyrification，被量化brainwide.Results：更多的自闭症特征的儿童表现出广泛的领域减少gyrification。在排除了具有最高自闭症特征和确诊ASD的儿童后，这种关联仍然存在于一个涉及左半球颞叶和楔前叶区域的大集群中。可比的，但不显着的影响时，比较一个小样本的确认ASD病例与年龄和性别匹配的对照subjects observed.Conclusions：皮质形态的差异与自闭症特征沿着一个连续的一个大的人口为基础的样本的学龄儿童被发现。这些发现支持将自闭症特征的神经生物学扩展到普通人群。
Objective: Recent evidence suggests that symptoms of social impairment in autism spectrum disorder (ASD) form a spectrum that extends into the general population. However, it is unclear whether the neuroanatomy of ASD also shows a similar continuum in the general population. Therefore, the goat of the present study was to investigate the relationship between cortical morphology and autistic traits along a continuum in a large population-based sample of young children.Method: The study included 717 children, aged 6-10 years, who are participants in the Generation R Study, a large population-based cohort. Autistic traits were measured using the Social Responsiveness Scale when the children were approximately 6 years old. High-resolution MRI was obtained, and morphological measures of the cortex, including cortical thickness and gyrification, were quantified brain-wide.Results: Children with more autistic traits showed widespread areas of decreased gyrification. After excluding children with the highest autistic traits and confirmed ASD, the association remained present in a large cluster involving the left hemisphere temporal and precuneus regions. Comparable, but nonsignificant effects when comparing a small sample of confirmed ASD case subjects with age- and gender-matched control subjects were observed.Conclusions: Differences in cortical morphology related to autistic traits along a continuum in a large population-based sample of school-aged children were found. Part of these differences remained after excluding the most severely affected children. These findings lend support to an extension of the neurobiology of autistic traits to the general population.