EFFECT OF KETOSIS ON RESPIRATORY SENSITIVITY TO CARBON-DIOXIDE IN OBESITY
EFFECT OF KETOSIS ON RESPIRATORY SENSITIVITY TO CARBON-DIOXIDE IN OBESITY
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DOI：
10.1056/nejm197605132942003
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发表时间：
1976-01-01
影响因子：
158.5
通讯作者：
MARLISS, EB
中科院分区：
文献类型：
--
作者：
FRIED, PI;MCCLEAN, PA;MARLISS, EB
研究了肥胖低通气综合征的呼吸缺陷可能对饮食控制有反应的可能性。研究了低热量生酮方案对二氧化碳呼吸反应的影响，排除了体重或胸部力学的变化作为因素。6名反应迟钝的肥胖受试者(每毫米汞柱1.1 1分钟)和12名反应正常的受试者被禁食或给予每天400千卡的蛋白质饮食。在酮症期间，低反应者的二氧化碳反应增加了一倍以上(0.8.+-.0.1至1.8。+-。每毫米汞柱0.21次/分钟，P<；0.05)，而正常反应者则无变化。这一改善不能通过两组之间体重、肺功能、pH或酮症程度的变化来解释。在低反应受试者中，酮体浓度与二氧化碳反应呈显著正相关(r=0.7；P<；0.001)。通过饮食控制可以提高肥胖患者对二氧化碳的抑郁敏感度。
The possibility that the respiratory defect in the obesity-hypoventilation syndrome might respond to dietary manipulation was investigated. The effects of hypocaloric ketogenic regimens on the ventilatory response to CO2 were studied in a manner excluding changes in weight or thoracic mechanics as factors. Six obese subjects with hyporesponse (< 1.1 1/min per mm Hg) and 12 with normal response were fasted or given a diet containing 400 kcal/day of protein. During ketosis CO2 response more than doubled in those with hyporesponse (0.8 .+-. 0.1 to 1.8 .+-. 0.2 1/min per mm Hg, P < 0.05) but was unchanged in those with normal response. This improvement could not be accounted for by changes in weight, pulmonary function, pH or degree of ketosis between the 2 groups. A significant positive (r = 0.70; P < 0.001) correlation between ketone body concentrations and CO2 response was observed in subjects with hyporesponse. Depressed sensitivity to CO2 in obese patients can be increased by dietary manipulation.