AMMONIA AS A POTENTIAL MEDIATOR OF ADULT HUMAN PERIODONTAL INFECTION - INHIBITION OF NEUTROPHIL FUNCTION
AMMONIA AS A POTENTIAL MEDIATOR OF ADULT HUMAN PERIODONTAL INFECTION - INHIBITION OF NEUTROPHIL FUNCTION
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DOI：
10.1016/0003-9969(90)90159-8
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发表时间：
1990-01-01
影响因子：
3
通讯作者：
RYDER, MI
中科院分区：
文献类型：
--
作者：
NIEDERMAN, R;BRUNKHORST, B;RYDER, MI
中性粒细胞（多形核白细胞）是宿主防御系统的主要细胞。 因此，如果龈缝中的牙周病原体衍生物质显著抑制其功能，它们可能会改变细菌-宿主平衡，有利于细菌。 氨可以抑制中性粒细胞功能的假设进行了测试。 特别选择氨，因为牙周病原体产生大量的氨。 结果表明，氨可抑制中性粒细胞的吞噬、脱颗粒和氧代谢。 氨减少了吞噬多形核中性粒细胞的总数（对照组的66%），也减少了脱粒（对照组的61%）。 氨降低了静息和刺激中性粒细胞的氧代谢（分别为对照组的33%和42%）。 这些观察结果支持氨可抑制多形核白细胞功能的假设。 他们认为，氨在牙龈缝隙中的存在可能会增加患牙周病的风险。
Neutrophils (polymorphonuclear leucocytes) are the principal cell of the host defence system. Consequently, if periodontal pathogen-derived substances in the gingival crevice significantly inhibit their function, they could shift the bacterial-host balance in favour of the bacteria. The hypothesis that ammonia can inhibit neutrophil function was tested. Ammonia was specifically selected because periodontal pathogens produce substantial amounts of ammonia. The findings indicated that ammonia can inhibit neutrophil phagocytosis, degranulation and oxygen metabolism. Ammonia decreased the total number of phagocytosing polymorphonuclear neutrophils (66% of control) and also decreased degranulation (61% of control). Ammonia decreased oxygen metabolism of both resting and stimulated neutrophils (33 and 42% of control, respectively). These observations support the hypothesis that ammonia can inhibit the functions of polymorphonuclear leucocytes. They suggest that the presence of ammonia in the gingival crevice may increase the risk of development of periodonal disease.