Fluoxetine in drug-dependent delinquents with major depression: an open trial.
Fluoxetine in drug-dependent delinquents with major depression: an open trial.
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氟西汀治疗重度抑郁症药物依赖罪犯：一项公开试验。
DOI：
10.1089/cap.1997.7.87
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Crowley,TJ
中科院分区：
文献类型：
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作者：
Riggs,PD;Mikulich,SK;Coffman,LM;Crowley,TJ
虽然氟西汀可能比安慰剂更有效地治疗青少年抑郁症没有主要的合并症，很少有人知道抑郁症状的反应，抗抑郁药的青少年共病行为障碍（CD）和物质使用障碍（SUD）。在SUD住院治疗期间戒断滥用物质≥1个月后仍然或变得抑郁的男性青少年，在一项开放试验中接受≥7周的固定剂量20 mg氟西汀治疗。8名患有CD、SUD和重度抑郁症的青少年（年龄14-18岁）未停药或接受其他药物治疗。观察到临床医生（p< 0.01）和患者（p< 0.01）评定的十点抑郁量表平均评分、卡罗尔抑郁自评量表（p< 0.02）和临床总体印象的疾病严重程度评分（p< 0.01）改善≥50%。在8名青少年中，7名显示出明显的改善，并希望在试验后继续使用氟西汀。副作用轻微且短暂。无受试者因副作用需要减量或停药。氟西汀似乎有助于治疗物质依赖性犯罪者，其主要抑郁症持续存在或在戒断4周后出现。这些初步发现证明了在这些年轻人中进行对照试验的合理性。
Although fluoxetine might be more effective than placebo for treating adolescent depression without major comorbidity, little is known about the response of depressive symptoms to antidepressants in adolescents with comorbid conduct disorder (CD) and substance use disorders (SUD). Male adolescents, who remained or became depressed after ≥1 month of abstinence from abused substances during residential treatment for SUD, were treated in an open trial for ≥7 weeks with a fixed dose of 20 mg of fluoxetine. The eight adolescents (ages 14–18 years) with CD, SUD, and major depression were not in drug withdrawal or receiving other pharmacotherapy. A ≥50% improvement was observed in mean scores on Ten Point Depression Scale rated by clinician (p< 0.01) and patients (p< 0.01), Carroll SelfRatings for depression (p< 0.02), and Severity of Illness scores on the Clinical Global Impression (p< 0.01). Of the eight adolescents, seven showed marked improvement and wished to continue fluoxetine after the trial. Side effects were mild and transient. No subject required dosage reduction or discontinuation of medication because of side effects. Fluoxetine appeared useful in treating substance-dependent delinquents whose major depressions persisted or emerged after 4 weeks of abstinence. These preliminary findings justify a controlled trial in such youths.