Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana
Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana
复制标题
DOI：
10.1002/ptr.862
复制
发表时间：
2002-05-01
影响因子：
7.2
通讯作者：
Shoyama, Y
中科院分区：
文献类型：
--
作者：
Du, XM;Sun, NY;Shoyama, Y
Goodyerin 是从 Goodyera schlechtendaliana 的全草中分离出来的黄酮醇苷，已被用作生药金线莲的替代品。测定了古德耶林的药理作用，包括对啮齿动物自发运动活性的影响、戊巴比妥诱导的催眠作用以及对印防己毒素诱导的癫痫发作的抗惊厥活性。 Goodyerin 表现出显着且密切依赖性的镇静和抗惊厥作用。版权所有 (C) 2002 John Wiley Sons, Ltd.
Goodyerin is a flavonol glycoside isolated from the whole plants of Goodyera schlechtendaliana which has been used as a substitute for the crude drug, Anoectochilus formosanus. The pharmacological propel-ties of goodyerin were assayed for effects oil spontaneous locomotor activity, on pentobarbital-induced hypnosis, and on anticonvulsant activity against picrotoxin-induced seizures in rodents. Goodyerin exhibited a significant and close-dependent sedative and anticonvulsant effect. Copyright (C) 2002 John Wiley Sons, Ltd.