Oxidative decarboxylation of arylacetic acids in water: One-pot transition-metal-free synthesis of aldehydes and ketones
Oxidative decarboxylation of arylacetic acids in water: One-pot transition-metal-free synthesis of aldehydes and ketones
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DOI：
10.1016/j.tetlet.2017.06.013
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发表时间：
2017-07-19
影响因子：
1.8
通讯作者：
Bhat, Ramakrishna G.
中科院分区：
文献类型：
--
作者：
Mete, Trimbak B.;Khopade, Tushar M.;Bhat, Ramakrishna G.
研究了芳香乙酸在水中无过渡金属氧化脱羧一锅法合成芳香醛和芳香酮的反应。该方案依赖于sp（3）杂化碳在水中直接脱羧，而不会过度氧化成羧酸，浪费最少。反应机理进行了研究，并证明了该协议的应用在克规模。(C)2017爱思唯尔有限公司版权所有
One-pot transition-metal-free synthesis of aromatic aldehydes and ketones via oxidative decarboxylation of arylacetic acids in water is developed. Protocol relies on the direct decarboxylation of sp(3)-hybridized carbon in water without any over oxidation into carboxylic acids with minimal waste. Reaction mechanism is investigated and application of this protocol is demonstrated on a gram scale. (C) 2017 Elsevier Ltd. All rights reserved.