Plasma Levels of Enterolactone and Percentage Mammographic Density among Postmenopausal Women
Plasma Levels of Enterolactone and Percentage Mammographic Density among Postmenopausal Women
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绝经后妇女血浆肠内酯水平和乳房 X 光密度百分比
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
G. Ursin
中科院分区：
文献类型：
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作者：
A. Stuedal;I. Gram;Y. Bremnes;H. Adlercreutz;M. Veierød;G. Ursin
目的：某些植物雌激素，如木脂素，可以防止乳腺癌的发展。肠内酯是由肠道植物群从膳食前体如全谷物、蔬菜和水果产生的木脂素代谢物。已证明肠内酯具有弱雌激素和抗雌激素特性。我们决定检查血浆肠内酯水平与乳腺摄影密度（乳腺癌风险的生物标志物）之间的关系。方法：我们纳入了来自55岁及以上的绝经后妇女的数据，这些妇女参加了挪威特罗姆斯的一项横断面乳房X线检查研究。616名妇女接受了乳房X线照片、血浆肠内酯测量以及人体测量和激素/生殖因素信息。我们使用先前验证的计算机辅助方法评估乳腺摄影密度。我们估计相关系数，并进行多元回归分析。结果如下：在肠内酯的四分位数中，平均乳腺摄影密度略有增加;与最低四分位数相比，最高四分位数的妇女的乳腺摄影密度平均高出3.1%（绝对差异）（P趋势<0.01）。校正年龄、体重指数、足月妊娠次数、首次生育年龄和绝经后激素治疗后，密度的平均差异降低至2.0%（P趋势= 0.05）。当仅限于454名目前的激素非使用者时，结果相似。完全校正的统计模型解释了乳腺摄影百分比密度总变异的28.3%，体重指数贡献了18.2%，肠内酯仅占0.9%。结论：在我们的研究中，较高水平的肠内酯与略高的乳腺摄影密度百分比相关。我们的研究结果表明，如果较高的肠内酯水平降低绝经后妇女患乳腺癌的风险，那么这种作用不是通过降低乳腺摄影密度。
Aims: Certain phytoestrogens, such as lignans, may protect against developing breast cancer. Enterolactone is a lignan metabolite produced by the intestinal flora from dietary precursors such as whole grains, vegetables, and fruits. Enterolactone has been shown to have weak estrogenic and antiestrogenic properties. We decided to examine the association between plasma levels of enterolactone and mammographic density, a biomarker for breast cancer risk. Methods: We included data from postmenopausal women ages 55 and older who participated in a cross-sectional mammogram study in Tromsø, Norway. Mammograms, plasma enterolactone measurements, as well as information on anthropometric and hormonal/reproduction factors were available on 616 women. We assessed mammographic density using a previously validated computer-assisted method. We estimated correlation coefficients and conducted multiple regression analyses. Results: Mean mammographic density increased slightly across quartiles of enterolactone; the women in the highest quartile had, on average, 3.1% (absolute difference) higher percentage mammographic density compared with the lowest quartile (Ptrend < 0.01). After adjustment for age, body mass index, number of full-term pregnancies, age at first birth, and use of postmenopausal hormone therapy, the mean difference in density was reduced to 2.0% (Ptrend = 0.05). Results were similar when restricted to the 454 current hormone nonusers. The fully adjusted statistical model explained 28.3% of the total variability in mammographic percentage density, with body mass index contributing 18.2% and enterolactone only 0.9%. Conclusion: In our study, higher levels of enterolactone were associated with slightly higher percentage mammographic density. Our results suggest that if higher enterolactone levels reduce the risk of developing breast cancer in postmenopausal women, then this effect is not through lowering mammographic density.
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发表时间：
2002
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
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发表时间：
2002
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
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Dai,Qi;Franke,AdrianA;Jin,Fan;Shu,Xiao-Ou;Hebert,JamesR;Custer,LaurieJ;Cheng,Jiarong;Gao,Yu-Tang;Zheng,Wei
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发表时间：
1998
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
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作者：
Zeleniuch-Jacquotte,A;Adlercreutz,H;Akhmedkhanov,A;Toniolo,P
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新加坡华裔女性的乳房 X 光检查实质模式和自我报告的大豆摄入量。
DOI：
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发表时间：
2002
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
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作者：
Jakes,RupertW;Duffy,StephenW;Ng,Fook-Cheong;Gao,Fei;Ng,Eng-Hen;Seow,Adeline;Lee,Hin-Peng;Yu,MimiC
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Yu,MimiC
DOI：
10.1093/jnci/95.1.30
发表时间：
2003-01-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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作者：
Greendale, GA;Reboussin, BA;Ursin, G
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