SPECIFICATION OF MALE DEVELOPMENT IN CAENORHABDITIS-ELEGANS - THE FEM GENES
SPECIFICATION OF MALE DEVELOPMENT IN CAENORHABDITIS-ELEGANS - THE FEM GENES
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DOI：
10.1016/0012-1606(84)90279-3
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发表时间：
1984-01-01
影响因子：
2.7
通讯作者：
HIRSH, D
中科院分区：
文献类型：
--
作者：
KIMBLE, J;EDGAR, L;HIRSH, D
fem-2基因的突变导致两性的雌性化：雌雄同体不产生精子，而雄性在中间性的体细胞性腺中产生卵母细胞。一个含有fem-1（原名disx-1; G. A.纳尔逊，K. K. Lew和S. Ward，1978，Dev. Biol.66，386 -409）和fem-2在限制性温度下导致XO动物（通常为雄性）转化为无精子的雌雄同体动物。每个雌激素基因突变体的表型、温度敏感期和母体效应都是相似的。这表明，无论是在雌雄同体的生殖系中，还是在雄性的体细胞和生殖系组织中，雌性基因都集中参与了秀丽隐杆线虫雄性发育的特化。
Mutation of the genefem-2causesfeminizationof both sexes: hermaphrodites make no sperm, and males produce oocytes in an intersexual somatic gonad. A double mutant harboringtsalleles of bothfem-1(formerly namedisx-1; G. A. Nelson, K. K. Lew, and S. Ward, 1978,Dev. Biol.66,386–409) andfem-2causes transformation of XO animals (normally male) into spermless hermaphrodites at restrictive temperature. The phenotypes, temperature-sensitive periods, and maternal effects observed in mutants of eachfemgene are found to be similar. It is suggested that thefemgenes are centrally involved in specification of male development inCaenorhabditis elegans—both in the germ line of hermaphrodites and in somatic and germ line tissues of males.