PROPERTIES OF STRAINS OF ESCHERICHIA-COLI CARRIED IN DIFFERENT PHASES OF ULCERATIVE-COLITIS
PROPERTIES OF STRAINS OF ESCHERICHIA-COLI CARRIED IN DIFFERENT PHASES OF ULCERATIVE-COLITIS
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DOI：
10.1136/gut.15.2.143
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发表时间：
1974-01-01
期刊：
影响因子：
24.5
通讯作者：
LENNARDJ.JE
中科院分区：
文献类型：
--
作者：
COOKE, EM;EWINS, SP;LENNARDJ.JE
菌株E.对活动期溃疡性结肠炎和缓解期结肠炎患者粪便中的大肠杆菌进行溶血素和坏死毒素检测。63例活动性结肠炎患者的培养物显示溶血性E。大肠杆菌23例（37%），缓解期24例（21%）（P<0.05）。相应比例的坏死毒素产生菌株为22%和12%。在35例结肠炎复发和缓解的患者中，14例改变了溶血性E的携带。其中13例在复发期携带溶血菌而在缓解期不携带，1例在缓解期携带溶血菌而在复发期不携带（P<0.01）。大肠杆菌也从19名患者的粪便标本中进行了检查，每周一次，共28周。获得溶血性或坏死性E。在这段期间，大肠杆菌菌株倾向于在四名病人发病后而不是发病前出现。在这19名患者中，当粪便中经常出现血液时，最常发现溶血性和坏死性菌株。这些事实表明，在结肠炎复发期间的肠道条件往往有利于溶血素和坏死毒素产生的生物体的存在，而不是这些生物体导致复发。来自用柳氮磺胺吡啶治疗的患者的大肠杆菌对磺胺吡啶49的敏感性测试是耐药的。结肠炎的活动性与27种血清型中任何一种的存在之间没有明确的关系。大肠杆菌检查。
Strains ofE. colifrom the faeces of patients with active ulcerative colitis and with colitis in remission were examined for haemolysin and necrotoxin production. Cultures from 63 patients with active colitis grew haemolyticE. coliin 23 (37%) as compared with 24 (21%) from 115 patients whose disease was in remission (p< 0·05). The corresponding proportions for necrotoxin-producing strains were 22% and 12%. Of 35 patients investigated both in relapse and remission of the colitis, 14 changed their carriage of haemolyticE. coli.Thirteen of these carried haemolytic organisms in relapse but not in remission, and one carried haemolytic organisms in remission but not in relapse (p< 0·01).Strains ofE. coliwere also examined from specimens of faeces obtained at weekly intervals for 28 weeks from 19 patients. The acquisition of haemolytic or necrotoxicE. colistrains tended to follow rather than precede the onset of the attack in the four patients who developed a relapse of the disease during this period. Among these 19 patients haemolytic and necrotoxic strains were found most commonly when blood was regularly present in the faeces. These facts suggest that conditions in the bowel during a relapse of colitis tend to favour the presence of haemolysin- and necrotoxin-producing organisms, rather than that these organisms cause the relapse.Of 50 strains ofE. colifrom patients treated with sulphasalazine tested for sensitivity to sulphapyridine 49 were resistant. There was no clear relation between the activity of the colitis and the presence of any of the 27 serotypes ofE. coliexamined.