Amelioration of postischaemic acute renal failure in conscious dogs by human atrial natriuretic peptide.
Amelioration of postischaemic acute renal failure in conscious dogs by human atrial natriuretic peptide.
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人心房钠尿肽改善清醒犬缺血后急性肾功能衰竭。
DOI：
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发表时间：
1990
影响因子：
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通讯作者：
K. Wagner
中科院分区：
文献类型：
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作者：
H. Neumayer;N. Blossei;U. Seherr;K. Wagner
我们研究了人ANP（α-hANP）-99-126对单侧肾切除的清醒狗的缺血后急性肾衰竭过程的影响，所述狗经受120分钟的肾缺血。与对照组A（n = 7）相比，研究组B（n = 9）在缺血后立即接受主动脉内推注100 μ g/kg α-hANP和0.3 μ g/kg/min × 180 min的额外连续输注。在缺血后第1天和第2天，仅重复推注。给予hANP导致GFR显著恢复（29 +/- 2 vs 18 +/- 4 ml/min，P ≤ 0.01），利尿（0.8 +/- 0.1 vs 0.5 +/- 0.1 ml/min，P小于或等于0.05）和尿钠排泄（44 +/- 7 vs 25 +/- 4 mumol/min，P小于或等于0.05），这反映在氮潴留减少（尿素：8 +/- 1 vs 12 +/- 2 mmol/l P小于或等于0.05，Pcrea：137 +/- 20 vs 204 +/- 37 mumol/l）。然而，肾灌注在缺血后第1天仅略有改善（198 +/- 20 vs 163 +/- 27 ml/min，N.S.）。我们的数据清楚地表明，反复推注应用hANP改善清醒犬的缺血后急性肾功能衰竭。我们假设观察到的对GFR的有益作用可能是肾小球毛细血管压力增加的结果，而不是肾灌注的改善。（250字处删节）
We studied the effect of human ANP (alpha-hANP)-99-126 on the course of postischaemic acute renal failure in unilaterally nephrectomised, conscious dogs subjected to 120 min of renal ischaemia. In contrast to a control group A (n = 7), the investigational group B (n = 9) received an intra-aortic bolus injection of 100 micrograms/kg alpha-hANP and an additional continuous infusion of 0.3 micrograms/kg per min x 180 min immediately after ischaemia. On days 1 and 2 after ischaemia, only the bolus injection was repeated. Administration of hANP resulted in a marked restoration of GFR (29 +/- 2 vs 18 +/- 4 ml/min, P less than or equal to 0.01), diuresis (0.8 +/- 0.1 vs 0.5 +/- 0.1 ml/min, P less than or equal to 0.05), and natriuresis (44 +/- 7 vs 25 +/- 4 mumol/min, P less than or equal to 0.05) on the first postischaemic day, which was mirrored by a reduction in nitrogen retention (Purea: 8 +/- 1 vs 12 +/- 2 mmol/l P less than or equal to 0.05, Pcrea: 137 +/- 20 vs 204 +/- 37 mumol/l). Renal perfusion, however, was only slightly improved on day 1 after ischaemia (198 +/- 20 vs 163 +/- 27 ml/min, N.S.). Our data clearly demonstrate that repeated bolus applications of hANP ameliorate postischaemic acute renal failure in conscious dogs. We assume that the observed beneficial effect on GFR might be the consequence of an increase in glomerular capillary pressure rather than an improvement of renal perfusion.(ABSTRACT TRUNCATED AT 250 WORDS)