Carbazolylmethylphosphonate compounds - Synthesis, coordination and fluorescence in solution and cells
Carbazolylmethylphosphonate compounds - Synthesis, coordination and fluorescence in solution and cells
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DOI：
10.1016/j.poly.2009.09.026
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发表时间：
2009-12-08
期刊：
影响因子：
2.6
通讯作者：
Wilson, John
中科院分区：
文献类型：
--
作者：
Buchaca, Ester;Man, Siud Pui;Wilson, John
化合物二乙基-N-咔唑基甲基膦酸酯 I 和二乙基-2-氧基甲基膦酸酯咔唑 2 已被合成并通过一系列技术进行表征，包括核磁共振、吸收和发射光谱、红外和质谱。化合物I与硝酸钙形成2:1配合物3，并描述了3的单晶X射线衍射结构。在乙醇中用 Zn2+ 和 Ca2+ 滴定 I 表明，在微摩尔乙醇溶液中存在这些金属离子时，固有荧光仅受到轻微干扰。化合物 I 和 2 在 L929 纤维肉瘤和 DRG（背根神经节）细胞系中很容易被吸收和观察。 (C) 2009 Elsevier Ltd. 保留所有权利。
The compounds diethyl-N-carbazolylmethylphosphonate I and diethyl-2-oxymethylphosphonate carbazole 2 have been synthesised and characterized by a range of techniques including NMR, absorption and emission spectroscopy, infrared, and mass spectroscopy. Compound I forms a 2:1 complex 3 with calcium nitrate and the single crystal X-ray diffraction structure of 3 is described. Titrations of I with Zn2+ and Ca2+ in ethanol reveal that the intrinsic fluorescence is only slightly perturbed in the presence of these metal ions in micromolar ethanol solutions. Compounds I and 2 are readily taken up and visualized in L929 fibrosarcoma and DRG (Dorsal root ganglia) cell lines. (C) 2009 Elsevier Ltd. All rights reserved.