Toxicity of diphtheria toxin for lymphoblastoid cells is increased by conjugation to antilymphocytic globulin
Toxicity of diphtheria toxin for lymphoblastoid cells is increased by conjugation to antilymphocytic globulin
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通过与抗淋巴细胞球蛋白缀合，白喉毒素对类淋巴母细胞的毒性增加
作者：
P. Thorpe;W. Ross;A. Cumber;C. A. Hinson;D. C. Edwards;A. Davies
医学上迫切需要具有组织特异性的细胞毒剂。可以通过将自身缺乏固有特异性的细胞毒性材料与针对靶细胞特有的表面抗原的抗体缀合来生产此类试剂。各种药物，包括细胞毒性药物 1-7、放射性材料 8、放射增敏剂 9 和酶 10-11 已与抗肿瘤抗体共价偶联，试图生产此类抗肿瘤药物，但迄今为止，这些药物尚未始终能够治愈荷瘤动物。我们和其他人12-16一样，选择使用白喉毒素，因为我们认为肿瘤特异性抗原的缺乏，也许是由于它们在实体瘤中的可及性受到限制，因此有必要使用现有的最有效的细胞毒素。
THERE is a pressing need in medicine for cytotoxic agents with tissue specificity. It may be possible to produce such agents by conjugating cytotoxic materials, themselves lacking inherent specificity, to antibodies directed against surface antigens peculiar to target cells. Various agents, including cytotoxic drugs1–7, radioactive materials8, radiosensitising agents9 and enzymes10–11 have been covalently coupled to antitumour antibodies in attempts to produce such antitumour agents but so far these have not consistently produced cures in tumour-bearing animals. We, like others12–16, have chosen to use diphtheria toxin because we consider that the paucity of tumour-specific antigens, accentuated, perhaps, by their restricted accessibility in solid tumours, necessitates the use of the most potent cytotoxins available.