SILICONE BREAST IMPLANT - ASSOCIATED MUSCULOSKELETAL MANIFESTATIONS
SILICONE BREAST IMPLANT - ASSOCIATED MUSCULOSKELETAL MANIFESTATIONS
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DOI：
10.1007/bf02207934
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发表时间：
1995-11-01
影响因子：
3.4
通讯作者：
ESPINOZA, R
中科院分区：
文献类型：
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作者：
CUELLAR, ML;GLUCK, O;ESPINOZA, R
连续300例接受硅胶乳房植入体（SBI）的女性，因各种肌肉骨骼疾病转诊至关节炎诊所，评价是否存在潜在结缔组织疾病。进行完整的病史和体格检查，以及C反应蛋白、类风湿因子和自身抗体间接免疫荧光和免疫扩散测定的实验室检测。该组平均年龄为44.4岁（范围：25-69岁），从初次植入手术到出现症状的平均时间为6.8年（范围：6个月-19岁），83.3%的研究女性的临床表现高度提示潜在结缔组织疾病。54%符合纤维肌痛和/或慢性疲劳综合征的标准，11%检测到明显的结缔组织疾病，10.6%发现未分化的结缔组织疾病或人类辅助疾病，以及各种疾病，如血管神经性水肿，冻结肩，多发性硬化样综合征。其他几种杂项条件，包括经常性和原因不明的低热，脱发，皮疹，干燥症状，雷诺现象，腕管综合征，记忆力丧失，头痛，胸痛，呼吸急促也被视为伴随特定和非特定条件。70%的接受植入物复位的患者报告其全身炎症改善。一个显着比例的SBI患者转介风湿性评估的临床表现高度提示;一个潜在的结缔组织疾病。此外，在超过一半的患者中，种植体植入后，他们的口腔学得到了改善。
Three hundred consecutive women with silicone breast implants (SBI), referred to the arthritis clinic with a variety of musculoskeletal complaints, were evaluated for the presence of underlying connective tissue disease. A complete history and physical examination were performed, as well as laboratory testing for C-reactive protein, rheumatoid factor, and autoantibody determination by indirect immunofluorescence and immunodiffusion. The group mean age was 44.4 years (range 25-69), the mean time from initial implant surgery to appearance of symptoms was 6.8 years (range: 6m-19y) and 83.3% of women studied had clinical manifestations highly suggestive of an underlying connective tissue disorder. Fifty-four percent met criteria for fibromyalgia and/or chronic fatigue syndrome, distinct connective tissue diseases was detected in 11%, undifferentiated connective tissue disease or human adjuvant disease was found in 10.6%, and a variety of disorders such as angioneurotic oedema, frozen shoulder, multiple sclerosis-like syndrome were present. Several other miscellaneous conditions including recurrent and unexplained low grade fever, hair loss, skin rash, sicca symptoms, Raynaud's phenomenon, carpal tunnel syndrome, memory loss, headaches, chest pain, and shortness of breath were also seen accompanying specific and non-specific conditions. Seventy percent of patients who underwent explantation of the implants reported improvement of their systemic symptomatology. A significant proportion of SBI patients referred for rheumatic evaluation have clinical manifestations highly suggestive of;an underlying connective tissue disease. Furthermore, improvement of their symptomatology follows explantation of the implants in over half of the patients.