Validation of a telephone zygosity questionnaire in twins of known zygosity
Validation of a telephone zygosity questionnaire in twins of known zygosity
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DOI：
10.1023/a:1021416112215
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发表时间：
1998-05-01
影响因子：
2.6
通讯作者：
Derom, R
中科院分区：
文献类型：
--
作者：
Peeters, H;Van Gestel, S;Derom, R
The aim of this study was to validate a zygosity questionnaire that can be administered over the telephone. Mothers of same-sexed twins of known zygosity and chorionicity between 2 and 31 years of age were interviewed on a nine-item questionnaire. From the answers one unweighted and four weighted indices were computed. As single questions, the mother's opinion and the "two peas in a pod" question differentiated best between monozygotic and dizygotic twins. One independent well-trained observer assessed the zygosity based on the questionnaire and made the correct diagnosis in 96% of the cases. A weighted index of eight similarity questions yielded an accuracy of 98%. This study shows that the zygosity of same-sexed twins more than 2 years old and without gross physical malformation can reliably be determined by a telephone questionnaire with a high accuracy.
