MURINE HERPESVIRUS 68 IS GENETICALLY RELATED TO THE GAMMAHERPESVIRUSES EPSTEIN-BARR-VIRUS AND HERPESVIRUS SAIMIRI
MURINE HERPESVIRUS 68 IS GENETICALLY RELATED TO THE GAMMAHERPESVIRUSES EPSTEIN-BARR-VIRUS AND HERPESVIRUS SAIMIRI
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DOI：
10.1099/0022-1317-71-6-1365
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发表时间：
1990-06-01
影响因子：
3.8
通讯作者：
GOMPELS, UA
中科院分区：
文献类型：
--
作者：
EFSTATHIOU, S;HO, YM;GOMPELS, UA
对鼠疱疹病毒68（MHV-68）DNA的7个限制性片段进行了短核苷酸序列分析，并用于确定该病毒的整体基因组结构和与其他α、β和γ疱疹病毒亚组的良好表征代表的相关性。已经鉴定了9个基因，其编码的氨基酸序列与γ疱疹病毒Epstein-Barr病毒（EBV）的蛋白质的相似性大于与α疱疹病毒水痘-带状疱疹病毒和单纯疱疹病毒1型或β疱疹病毒人巨细胞病毒的同源产物的相似性。此外，MHV-68的基因组组织显示与γ疱疹病毒EBV和疱疹病毒松鼠猴的基因组组织具有总体共线性。与这些病毒一样，MHV-68编码序列的二核苷酸频率分析显示CpG二核苷酸频率显著降低，因此暗示分裂细胞群为体内潜伏位点。
Short nucleotide sequence analysis of seven restriction fragments of murine herpesvirus 68 (MHV-68) DNA has been undertaken and used to determine the overall genome organization and relatedness of this virus to other well characterized representatives of the alpha-, beta- and gammaherpesvirus subgroups. Nine genes have been identified which encode amino acid sequences with greater similarity to proteins of the gammaherpesvirus Epstein-Barr virus (EBV) than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simples virus type 1 or the betaherpesvirus human cytomegalovirus. In addition, the genome organization of MHV-68 is shown to have an overall collinearity with that of the gamma herpesviruses EBV and herpesvirus saimiri. In common with these viruses, dinucleotide frequency analysis of MHV-68 coding sequences reveals a marked reduction in CpG dinucleotide frequency thus implicating a dividing cell population as the site of latency in vivo.