Depressive symptoms, race, and circulating C-reactive protein: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Depressive symptoms, race, and circulating C-reactive protein: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
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DOI：
10.1097/psy.0b013e3181ec4b98
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发表时间：
2010-10
影响因子：
3.3
通讯作者：
Matthews KA
中科院分区：
文献类型：
--
作者：
Deverts DJ;Cohen S;DiLillo VG;Lewis CE;Kiefe C;Whooley M;Matthews KA
研究抑郁症状与循环C反应蛋白（CRP）的前瞻性关联，并确定该关联的方向。使用来自年轻人冠状动脉风险发展（CARDIA）研究（年龄33-45岁，55%女性，42%黑人）的2544名健康参与者的数据，我们检查了抑郁症状的前瞻性关联，通过流行病学研究中心抑郁量表（CES-D）测量，5年后循环CRP。CARDIA第15年的抑郁症状可预测第20年的CRP，与人口统计学特征、生物学和医学风险因素、健康行为和第15年CRP无关。然而，这种关联是以种族为条件的，例如CRP的增加与抑郁症状的增加存在于黑人中，而不是白人。无论是黑人还是白人，15岁的CRP都不能预测20岁的抑郁症状。在黑人参与者中，当在单独的分析中进行检查时，CES-D的抑郁情绪和躯体症状子量表得分较高，积极情绪子量表得分较低，与20岁以上CRP相关。人际关系问题分量表与CRP无关。当所有四个分量表分数同时进入同一模型，黑人参与者的积极情感和躯体症状分量表的分数出现作为独立的预测因子20年CRP，而抑郁情绪和人际关系问题分量表没有。抑郁症状可能与黑人的炎症比白人更密切相关。
To examine the prospective association of depressive symptoms with circulating C-reactive protein (CRP) and determine the direction of that association. Using data from 2544 healthy participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study (ages 33–45, 55% female, 42% black), we examined the prospective association of depressive symptoms, as measured by the Centers for Epidemiologic Studies Depression Scale (CES-D), with circulating CRP five years later. Depressive symptoms at CARDIA Year 15 predicted CRP at Year 20, independent of demographic characteristics, biological and medical risk factors, health behaviors, and Year 15 CRP. This association, however, was conditional upon race such that the increase in CRP with increasing depressive symptoms was present in blacks but not whites. In neither blacks nor whites did Year 15 CRP predict Year 20 depressive symptoms. Among black participants, when examined in separate analyses, higher scores on the depressed affect and somatic symptoms subscales of the CES-D, and lower scores on the positive affect subscale were associated with greater Year 20 CRP. The interpersonal problems subscale was unrelated to CRP. When all four subscale scores were entered simultaneously in the same model, black participants' scores on the positive affect and somatic symptoms subscales emerged as independent predictors of Year 20 CRP whereas the depressed affect and interpersonal problems subscales did not. Depressive symptoms may be more closely linked to inflammation in blacks than in whites.