Visual motion processing investigated using contrast agent-enhanced fMRI in awake behaving monkeys
Visual motion processing investigated using contrast agent-enhanced fMRI in awake behaving monkeys
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DOI：
10.1016/s0896-6273(01)00502-5
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发表时间：
2001-11-20
期刊：
影响因子：
16.2
通讯作者：
Orban, GA
中科院分区：
文献类型：
--
作者：
Vanduffel, W;Fize, D;Orban, GA
为了缩小人类神经成像与猕猴生理学和解剖学之间的信息差距，我们绘制了固定猴子的移动和静止刺激（随机点或线）产生的功能磁共振成像信号。相对于 BOLD 技术，通过注射造影剂（单晶氧化铁纳米颗粒 [MION]），功能灵敏度提高了 5 倍。被确定为运动敏感的区域包括 V2、V3、MT/V5、vMST、FST、VIP 和 FEF（带有移动点），以及 V4、TE、LIP 和 PIP（带有随机线）。这些对移动点敏感的区域与猴子单个单元数据和（V3A 除外）人类 fMRI 结果基本一致。移动线激活一些先前未涉及运动处理的区域。总的来说，结果阐明了灵长类动物的运动路径和背侧流之间的关系。
To reduce the information gap between human neuroimaging and macaque physiology and anatomy, we mapped fMRI signals produced by moving and stationary stimuli (random dots or lines) in fixating monkeys. Functional sensitivity was increased by a factor of similar to5 relative to the BOLD technique by injecting a contrast agent (monocrystalline iron oxide nanoparticle [MION]). Areas identified as motion sensitive included V2, V3, MT/V5, vMST, FST, VIP, and FEF (with moving dots), as well as V4, TE, LIP, and PIP (with random lines). These regions sensitive for moving dots are largely in agreement with monkey single unit data and (except for V3A) with human fMRI results. Moving lines activate some regions that have not been previously implicated in motion processing. Overall, the results clarify the relationship between the motion pathway and the dorsal stream in primates.