Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication.
Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication.
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谴责DNA合成：一种固有的重新启动途径，可保持有效的基因组复制。
DOI：
10.1093/nar/gkab176
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发表时间：
2021-05-21
影响因子：
14.9
通讯作者：
Doherty AJ
中科院分区：
文献类型：
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作者：
Bainbridge LJ;Teague R;Doherty AJ
To bypass a diverse range of fork stalling impediments encountered during genome replication, cells possess a variety of DNA damage tolerance (DDT) mechanisms including translesion synthesis, template switching, and fork reversal. These pathways function to bypass obstacles and allow efficient DNA synthesis to be maintained. In addition, lagging strand obstacles can also be circumvented by downstream priming during Okazaki fragment generation, leaving gaps to be filled post-replication. Whether repriming occurs on the leading strand has been intensely debated over the past half-century. Early studies indicated that both DNA strands were synthesised discontinuously. Although later studies suggested that leading strand synthesis was continuous, leading to the preferred semi-discontinuous replication model. However, more recently it has been established that replicative primases can perform leading strand repriming in prokaryotes. An analogous fork restart mechanism has also been identified in most eukaryotes, which possess a specialist primase called PrimPol that conducts repriming downstream of stalling lesions and structures. PrimPol also plays a more general role in maintaining efficient fork progression. Here, we review and discuss the historical evidence and recent discoveries that substantiate repriming as an intrinsic replication restart pathway for maintaining efficient genome duplication across all domains of life.
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影响因子：
16
作者：
Bianchi, Julie;Rudd, Sean G.;Jozwiakowski, Stanislaw K.;Bailey, Laura J.;Soura, Violetta;Taylor, Elaine;Stevanovic, Irena;Green, Andrew J.;Stracker, Travis H.;Lindsay, Howard D.;Doherty, Aidan J.
通讯作者：
Doherty, Aidan J.
影响因子：
4.8
作者：
Amado, Luciana;Kuzminov, Andrei
通讯作者：
Kuzminov, Andrei
影响因子：
56.9
作者：
Della, M;Palmbos, PL;Doherty, AJ
通讯作者：
Doherty, AJ
真核铅和滞后链DNA聚合酶通过单独的机制加载到引物上，但在PCNA存在下具有可比的加工性。
影响因子：
14.9
作者：
Chilkova O;Stenlund P;Isoz I;Stith CM;Grabowski P;Lundström EB;Burgers PM;Johansson E
通讯作者：
Johansson E
影响因子：
64.8
作者：
通讯作者：
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