PLATELET CONSUMPTION BY POLYVINYL-ALCOHOL COATED TUBING IN CANINES
PLATELET CONSUMPTION BY POLYVINYL-ALCOHOL COATED TUBING IN CANINES
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DOI：
10.1002/jbm.820250707
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发表时间：
1991-07-01
期刊：
影响因子：
--
通讯作者：
SEFTON, MV
中科院分区：
文献类型：
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作者：
IP, WF;SEFTON, MV
聚乙烯醇（PVA）涂层的聚乙烯管，有或没有固定肝素，引起严重的血小板减少症，并增加新的血小板的生产时，插入在犬的慢性动静脉分流。 与仅分流管（无试验段）相比，相似长度的无涂层聚乙烯管既不会导致血小板减少症，也不会显著增强血小板再生。 通过丙二醛测定法监测血小板再生，该测定法被认为可以区分“新”血小板和“旧”血小板。 这种区别与血小板计数值相结合，以便在存在非恒定血小板计数的情况下计算累积消耗曲线和初始部分消耗率。 得出的初始部分消耗率为：PVA为34%/天，聚乙烯为20.5%/天，仅分流管空白为18%/天。
Polyvinyl alcohol (PVA)-coated polyethylene tubing, with or without immobilized heparin, caused severe thrombocytopenia and enhanced the production of new platelets when inserted in a chronic arteriovenous shunt in canines. A similar length of uncoated polyethylene tubing neither lead to thrombocytopenia nor significantly enhanced platelet regeneration, relative to the shunt only without a test section. Platelet regeneration was monitored by the malondialdehyde assay, which was assumed to make a distinction between "new" and "old" platelets. This distinction was combined with the platelet count values to enable calculation of the cumulative consumption curve and the initial fractional consumption rate in the presence of a non constant platelet count. The resulting initial fractional consumption rates were: 34%/day for PVA, 20.5%/day for polyethylene, and 18%/day for the shunt only blank.