Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrapulmonary lesions
Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrapulmonary lesions
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DOI：
10.1097/jto.0b013e31818396b9
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发表时间：
2008-09-01
影响因子：
20.4
通讯作者：
Yoshino, Ichiro
中科院分区：
文献类型：
--
作者：
Nakajima, Takahiro;Yasufuku, Kazuhiro;Yoshino, Ichiro
背景：支气管镜检查无法发现的中央型肺内肿瘤的诊断可能是一个挑战。支气管内超声引导下经支气管针吸活检（EBUS-TBNA）已被证明可用于评价纵隔淋巴结。然而，有没有报告的实用性EBUS-TBNA诊断肺内tumors.Objectives：本研究的目的是评估的有用性EBUS-TBNA诊断肺内肿瘤位于附近的中央airway.Methods：从2002年12月至2007年6月，35例肺部肿块位于靠近中央airways.EBUS-TBNA访问。EBUS-TBNA前常规支气管镜活检在35例病例中有25例无法诊断。结果：19例气管周围病变和16例支气管周围病变均行EBUS-TBNA检查。35例患者中有33例的细胞学和/或组织学样本具有诊断性。最终诊断为肺癌26例（小细胞肺癌1例，非小细胞肺癌25例），肺转移瘤5例，BALT淋巴瘤1例。EBUS-TBNA诊断肺部不明肿块的敏感性为94.1%，诊断准确率为94.3%，EBUS-TBNA对肺部不明肿块的诊断敏感性为94.1%，EBUS-TBNA对肺部不明肿块的诊断准确率为94.3%，EBUS-TBNA对肺部不明肿块的诊断敏感性为94.1%，EBUS-TBNA对肺部不明肿块的诊断准确性为94.3%，EBUS-TBNA对肺部不明肿块的诊断敏感性为94.1%，EBUS-TBNA对肺部不明肿块的诊断准确性为94.3%，EBUS-TBNA对肺部不明肿块的诊断敏感性为94.3%，EBUS-TBNA对肺部不明肿块的诊断准确性为94.3%。EBUS-TBNA是一种实时、高诊断率的方法，可用于肺部肿瘤的诊断。
Background: The diagnosis of centrally located intrapulmonary tumors not visible on bronchoscopy may be a challenge. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been shown to be useful for the evaluation of mediastinal lymph nodes. However, there have been no reports of the utility of EBUS-TBNA for the diagnosis of intrapulmonary tumors.Objectives: The purpose of this study was to evaluate the usefulness of EBUS-TBNA for the diagnosis of intrapulmonary tumors located adjacent to the central airway.Methods: From December 2002 to June 2007, 35 patients with pulmonary masses located close to the central airways were accessed by EBUS-TBNA. Conventional bronchoscopic biopsy before EBUS-TBNA was nondiagnostic in 25 of the 35 cases. Patients with endobronchial lesions were excluded from this study.Results: EBUS-TBNA was performed in 19 peritracheal and 16 peribronchial lesions. Cytologic and/or histologic samples were diagnostic in 33 of 35 patients. The final diagnoses of the pulmonary masses were lung cancer in 26 cases (1 small cell lung cancer, 25 non-small cell lung cancer), metastatic lung tumors in 5, and BALT lymphoma in one. The sensitivity and the diagnostic accuracy Of EBUS-TBNA for the diagnosis of unknown pulmonary masses was 94.1% and 94.3%, respectively.Conclusions: Intrapulmonary lesions not assessable by conventional bronchoscopic procedures can easily be assessed and diagnosed by EBUS-TBNA as long as it is within the reach of the EBUS-TBNA scope. EBUS-TBNA is a real-time procedure with a high yield which can be applied for the diagnosis Of lung tumors.