Asymmetric allylation of aldehydes catalyzed by substoichiometric amounts of chiral phosphoramides
Asymmetric allylation of aldehydes catalyzed by substoichiometric amounts of chiral phosphoramides
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DOI：
10.1016/0040-4039(96)01040-4
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发表时间：
1996-07-15
影响因子：
1.8
通讯作者：
Kobayashi, Y
中科院分区：
文献类型：
--
作者：
Iseki, K;Kuroki, Y;Kobayashi, Y
亚化学计量的手性磷酰胺催化芳香醛与烯丙基三氯硅烷的不对称烯丙基化和巴豆基化反应，对映体过量高达88%ee。由（S）-脯氨酸制备的磷酰胺3和4分别得到手性高烯丙醇6和它们的对映体7，具有相似水平的对映选择性。版权所有（C）1996 Elsevier Science Ltd
The asymmetric allylation and crotylation of aromatic aldehydes with allylic trichlorosilanes catalyzed by substoichiometric quantities of chiral phosphoramides were carried our with good enantiomeric excess (up to 88% ee). Phosphoramides 3 and 4, prepared from (S)-proline, gave chiral homoallylic alcohols 6 and their enantiomers 7, respectively, with similar levels of enantioselectivity. Copyright (C) 1996 Elsevier Science Ltd