Combined Atropine with Orthokeratology for Myopia Control: Study Design and Preliminary Results
Combined Atropine with Orthokeratology for Myopia Control: Study Design and Preliminary Results
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DOI：
10.1080/02713683.2019.1568501
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发表时间：
2019-06-03
影响因子：
2
通讯作者：
Cho, Pauline
中科院分区：
文献类型：
--
作者：
Tan, Qi;Ng, Alex L. K.;Cho, Pauline
目的：本研究的目的是介绍一项为期2年的随机试验的研究设计和一个月的初步结果，阿托品与角膜塑形术（AOK）相结合，用于近视对照研究。在1个月访视时，首次验配成功率为95%，近视完全降低。配戴透镜1个月后，AOK组和OK组分别有23.3%和30.9%的患者观察到轻度角膜染色，50%和41%的患者自我报告透镜粘合。是说AOK组眼轴长度的变化（标准差）显著高于OK组（AOK：-0.05 +/- 0.05 mm; OK：-0.02 +/- 0.03 mm）结论：治疗1个月后，两组患者角膜塑形镜的首次验配成功率均较高;在AOK受试者中添加0.01%阿托品不会影响透镜性能或临床反应。这些结果保证了继续进行这项纵向研究是可以接受的，因为需要更长的研究时间（通常为2年）来确定近视控制治疗的有效性。
Purpose: The purpose of this study is to present the study design and one month's preliminary results of a 2-year randomized trial, Combined Atropine with Orthokeratology (AOK), for myopia control study.Methods: Children aged 6 to 0.05). At the 1-month visit, first-fit success rate was 95%, with full myopia reduction. Mild corneal staining was observed in 23.3% and 30.9% and mild self-reported lens binding in 50% and 41% in AOK and OK groups, respectively, after 1-month lens wear. Mean (standard deviation) change in axial length was significantly higher in AOK than OK subjects (AOK: -0.05 +/- 0.05 mm; OK: -0.02 +/- 0.03 mm) (P =0.003).Conclusions: After 1month of treatment, first-fit success rate of ortho-k lenses was high in both groups of subjects; addition of 0.01% atropine in AOK subjects did not affect the lens performance or clinical responses. These results provide the assurance that it is acceptable to continue this longitudinal study, as longer study duration, usually 2years, is required to determine the effectiveness of treatment for myopia control.