Accuracy of in vivo multimodal optical imaging for detection of oral neoplasia.
Accuracy of in vivo multimodal optical imaging for detection of oral neoplasia.
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DOI：
10.1158/1940-6207.capr-11-0555
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Gillenwater AM
中科院分区：
文献类型：
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作者：
Pierce MC;Schwarz RA;Bhattar VS;Mondrik S;Williams MD;Lee JJ;Richards-Kortum R;Gillenwater AM
如果及早发现，口腔癌是可以治愈的。然而，口腔癌患者的生存率仍然很低，主要是由于晚期诊断和随后的治疗困难。为了提高临床医生检测早期疾病和治疗晚期癌症的能力，我们开发了一种多模态光学成像系统（MMIS），以在宏观和微观尺度上原位评估组织。MMIS用于测量30例患者的100个解剖部位，正确分类98%的病理证实的正常组织部位，95%的部位被分级为中度异型增生、重度异型增生或癌症。当单独使用时，MMIS分类的准确性为35%，病理学确定为轻度异型增生的网站。然而，MMIS测量与87%的轻度异型增生部位的候选分子标记物表达相关。这些发现支持非侵入性多模态光学成像准确识别肿瘤组织和癌前病变的能力。这反过来可能对口腔癌和其他上皮恶性肿瘤患者的检测和治疗产生相当大的影响。
If detected early, oral cancer is eminently curable. However, survival rates for oral cancer patients remain low, largely due to late stage diagnosis and subsequent difficulty of treatment. To improve clinicians’ ability to detect early disease and to treat advanced cancers, we developed a multi-modal optical imaging system (MMIS) to evaluate tissue in situ, at macroscopic and microscopic scales. The MMIS was used to measure anatomical 100 sites in 30 patients, correctly classifying 98% of pathologically confirmed normal tissue sites, and 95% of sites graded as moderate dysplasia, severe dysplasia, or cancer. When used alone, MMIS classification accuracy was 35% for sites determined by pathology as mild dysplasia. However, MMIS measurements correlated with expression of candidate molecular markers in 87% of sites with mild dysplasia. These findings support the ability of non-invasive multi-modal optical imaging to accurately identify neoplastic tissue and pre-malignant lesions. This in turn may have considerable impact on detection and treatment of patients with oral cancer and other epithelial malignancies.