The DeltaCrit System (DCS):: a computer program for standardized bedside detection of critical oxygen delivery using the Deltatrac II™ metabolic monitor
The DeltaCrit System (DCS):: a computer program for standardized bedside detection of critical oxygen delivery using the Deltatrac II™ metabolic monitor
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DOI：
10.1016/s0010-4825(03)00015-5
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发表时间：
2003-09-01
影响因子：
7.7
通讯作者：
Habler, O
中科院分区：
文献类型：
--
作者：
Meier, J;Wölkhammer, S;Habler, O
在静息状态下，组织的耗氧量（VO 2）等于其O-2需求量。然而，当氧输送（DO 2）下降到“临界”值以下，连续下降的VO 2反映了一个关键的限制DO？可靠的床旁VO 2显著下降检测需要使用代谢监测仪连续测量吸气和呼气O-2浓度以及对所获得的数据进行标准化在线分析。然而，在这方面还没有标准化的程序。因此，开发了DeltaCrit-System（DCS），能够在线检测VO 2显著下降，表明DO 2严重受限。在VO 2值稳定的参考期后，DCS测试随后测量的VO 2值是否显著低于平均基线VO 2。一个显着的VO 2减少应表明由于DO 2的关键限制的VO 2的O-2供应依赖性的开始。DCS已通过9个不同的人工生成的数据集进行了验证，并已在一个动物实验中进行了测试。DCS已被证明具有一致性，因此可被视为一种新工具，允许临床医生在早期识别DO 2的限制，并开始早期治疗干预。(C)2003爱思唯尔有限公司。保留所有权利。
Under resting conditions oxygen consumption (VO2) of the tissues equals their O-2 demand. However, when oxygen delivery (DO2) decreases below "a critical" value, the consecutive decline of VO2 reflects a critical restriction of DO? resulting in the onset of tissue hypoxia.Reliable bedside detection of a significant VO2 decline requires continuous measurement of in- and exspiratory O-2 concentrations with a metabolic monitor as well as a standardized online analysis of the data obtained. However, for this purpose no standardized procedure was available yet. Therefore, the DeltaCrit-System (DCS) has been developed enabling online detection of a significant VO2 decline indicating critical restriction of DO2.After a reference period with stable VO2 values the DCS tests whether a subsequently measured VO2 value is significantly lower than the mean baseline VO2. A significant VO2 decrease should indicate the onset of O-2 supply dependency of VO2 due to a critical restriction of DO2. The DCS has been validated with nine different, artificially generated data sets and has been tested in one animal experiment.DCS has proven consistency and may therefore be considered a new tool allowing clinicians to recognize restrictions in DO2 at an early time, and to start early therapeutic interventions. (C) 2003 Elsevier Ltd. All rights reserved.