Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: is it common or rare?
Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: is it common or rare?
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DOI：
10.1007/s00330-004-2502-2
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发表时间：
2005-06-01
影响因子：
5.9
通讯作者：
Manav, A
中科院分区：
文献类型：
--
作者：
Coskun, A;Yikilmaz, A;Manav, A
苍白球受累是急性核黄疸的一个众所周知的磁共振（MR）成像发现。然而，目前尚不清楚苍白球的累及有多早，以及是否在所有病例中都能看到。因此，我们的目的是探讨苍白球参与13例新生儿急性核黄疸的磁共振成像。对13例因黄疸、脑病和间接高胆红素血症（平均37.0 mg/dl）入院的新生儿进行前瞻性头颅MR成像评估。苍白球可见病理信号改变。13例患者中有8例在T1加权MR成像上表现为双侧苍白球对称性信号增强。这些病变在T2加权像上不明显。1例无苍白球受累，脑实质多发点状T1高信号病灶。这种表现与出血一致。另外4例患者的MRI检查结果显示无异常证据。苍白球对称性受累在T1加权像上呈高信号是急性核黄疸常见的特征性表现。
Globus pallidus involvement is a well-known magnetic resonance (MR) imaging finding of acute kernicterus. However, it is not clear how early the involvement of globus pallidus occurs and whether or not it is seen in every case. Therefore, we aimed to investigate the globus pallidus involvement in 13 neonates with acute kernicterus by MR imaging. Thirteen neonates who were admitted with jaundice, encephalopathy and indirect hyperbilirubinemia (mean, 37.0 mg/dl) were prospectively evaluated with cranial MR imaging. Pathological signal changes were noted concerning the globus pallidus. Eight of the 13 patients demonstrated bilateral, symmetric increased signal intensity in the globus pallidus on T1-weighted MR imaging. These lesions were not apparent on T2-weighted images. Multiple parenchymal punctuate T1 hyperintense lesions were detected in one patient without globus pallidus involvement. This appearance was consistent with hemorrhage. The MR imaging findings of the other four patients showed no evidence of abnormality. The symmetric involvement of globus pallidus seen as hyperintense on T1-weighted MR imaging is a common and characteristic finding of acute kernicterus.