Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome.
Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome.
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DOI：
10.1126/sciadv.add2185
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发表时间：
2022-12-14
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞结构的皮质变化形成了感觉-离体轴，它塑造了外部连接的区域轮廓，并被认为可以引导信号在整个皮质层次结构中的传播和整合。虽然神经影像学工作表明该轴限制了人类连接组的局部特性，但目前尚不清楚它是否也塑造了由高阶拓扑产生的不对称信号传导。在这里，我们使用网络控制理论来检查跨感觉逸轴传播动力学所需的能量。我们的结果揭示了这种能量的不对称性，表明自下而上的转变比自上而下的转变更容易完成。支持分析表明，不对称性是由连接组拓扑结构支撑的，该拓扑结构通过连接来支持有效的自下而上的信号传导。最后，我们发现不对称性与沟通能力和内在神经元时间尺度的差异相关，并且在整个青年时期减少。我们的结果表明，细胞结构的皮质变化可能指导宏观连接组拓扑的形成。将微观结构与连接组联系起来表明，活动在皮质层次结构中向上传播比向下传播更有效。
Cortical variations in cytoarchitecture form a sensory-fugal axis that shapes regional profiles of extrinsic connectivity and is thought to guide signal propagation and integration across the cortical hierarchy. While neuroimaging work has shown that this axis constrains local properties of the human connectome, it remains unclear whether it also shapes the asymmetric signaling that arises from higher-order topology. Here, we used network control theory to examine the amount of energy required to propagate dynamics across the sensory-fugal axis. Our results revealed an asymmetry in this energy, indicating that bottom-up transitions were easier to complete compared to top-down. Supporting analyses demonstrated that asymmetries were underpinned by a connectome topology that is wired to support efficient bottom-up signaling. Lastly, we found that asymmetries correlated with differences in communicability and intrinsic neuronal time scales and lessened throughout youth. Our results show that cortical variation in cytoarchitecture may guide the formation of macroscopic connectome topology. Linking microstructure to the connectome shows that activity propagates more efficiently up the cortical hierarchy than down.
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