Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion.
Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion.
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DOI：
10.1038/ncpuro1296
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Montgomery, Bruce
中科院分区：
文献类型：
--
作者：
Harris, William P.;Mostaghel, Elahe A.;Nelson, Peter S.;Montgomery, Bruce
雄激素剥夺疗法仍然是晚期前列腺癌男性治疗的关键组成部分，数据支持其用于转移性疾病，并在特定情况下与手术或放疗结合使用。标准雄激素剥夺疗法的替代方案，如间歇性雄激素抑制和雌激素治疗，在保持临床效益的同时，有可能改善毒性概况。目前的雄激素剥夺策略似乎不能完全抑制雄激素水平和雄激素受体在组织水平上的介导作用。随着对去势抵抗性前列腺癌机制的了解不断深入，针对雄激素代谢和雄激素受体的治疗方法将得到合理设计。研究初级雄激素剥夺疗法优化的大型试验的结果，包括间歇性雄激素抑制和雌激素贴片评估的评估，以及新型雄激素合成抑制剂（如醋酸阿比特龙）的III期研究，都迫切需要等待。
Androgen deprivation therapy remains a critical component of treatment for men with advanced prostate cancer, and data supports its use in metastatic disease and in conjunction with surgery or radiation in specific settings. Alternatives to standard androgen deprivation therapy, such as intermittent androgen suppression and estrogen therapy, hold the potential to improve toxicity profiles while maintaining clinical benefit. Current androgen deprivation strategies seem to incompletely suppress androgen levels and androgen-receptor-mediated effects at the tissue level. Advances in the understanding of mechanisms that contribute to castration-resistant prostate cancer are leading to rationally designed therapies targeting androgen metabolism and the androgen receptor. The results of large trials investigating the optimization of primary androgen deprivation therapy, including evaluation of intermittent androgen suppression and estrogen patch assessment, as well as phase III studies of novel androgen synthesis inhibitors, such as abiraterone acetate, are eagerly awaited.
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影响因子：
2.1
作者：
Higano, CS;Ellis, W;Lange, PH
通讯作者：
Lange, PH
影响因子：
4.5
作者：
Boccon-Gibod, Laurent;Hammerer, Peter;Tunn, Ulf
通讯作者：
Tunn, Ulf
影响因子：
45.3
作者：
D'Amico, Anthony V.;Chen, Ming-Hui;Kantoff, Philip W.
通讯作者：
Kantoff, Philip W.
影响因子：
4.8
作者：
Askew, Emily B.;Gampe, Robert T., Jr.;Wilson, Elizabeth M.
通讯作者：
Wilson, Elizabeth M.
DOI：
10.1093/jnci/91.21.1869
发表时间：
1999-11-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Agus, DB;Cordon-Cardo, C;Scher, HI
通讯作者：
Scher, HI