Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes
Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes
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DOI：
10.1016/j.bpc.2008.03.005
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发表时间：
2008-06-01
影响因子：
3.8
通讯作者：
Stevanato, Roberto
中科院分区：
文献类型：
--
作者：
Fabris, Sabrina;Momo, Federico;Stevanato, Roberto
比较了其更广泛的糖硅酸酯衍生物traps-白藜芦醇（traps-3,5,4'-三羟基苯乙烯）和traps-piceid （traps-5,4' -二羟基苯乙烯-3- o - β - d -葡萄糖吡喃苷）的抗氧化活性，测定了它们对亚油酸（LA）过氧化的抑制作用以及对不同自由基（如DPPH）和自由基引发剂的清除能力。研究发现，这两种二苯乙烯具有相似的抗氧化能力，而与BHT（2,6-二叔丁基-4-甲基苯酚）和α -生育酚（维生素E，维生素E）的比较。E)作为参考，指出了对脂质过氧化的缓慢但持久的保护作用。此外，杉木酸似乎比白藜芦醇更有效，这是后者与其自由基形式反应的结果。不同链长磷脂酰胆碱脂质体的DSC谱图和自旋标记脂质体的EPR测量表明，这些化合物的敏感羟基位于双分子层的脂质区域，靠近多不饱和脂肪酸的双键，使这些二苯乙烯特别适合于预防和控制膜的脂质过氧化。(c) 2008 Elsevier B.V.版权所有
The antioxidant activities of traps-resveratrol (traps-3,5,4'-trihydroxystilbene) and traps-piceid (traps-5,4'dihydroxystilbene-3-O-beta-D-glucopyranoside), its more widespread glycosilate derivative, have been compared measuring their inhibitory action on peroxidation of linoleic acid (LA) and the radical scavenging ability towards different free radicals (such as DPPH) and radical initiators. It has been found that the two stilbenes have similar antioxidant capacity, while the comparison with BHT (2,6-di-tert-butyl-4-methylphenol) and alpha-tocopherol (vitamin E, vit. E), taken as reference, points out a slower but prolonged protective action against lipid peroxidation. Furthermore, piceid appears more efficacious than resveratrol as a consequence of the reaction of the latter with its radical form.The DSC profiles of phosphatidylcholine liposomes of various chain lengths, and EPR measurements of spin labelled liposomes demonstrated that the susceptible hydroxyl group of these compounds are located in the lipid region of the bilayer close to the double bonds of polyunsatured fatty acids, making these stilbenes particularly suitable for the prevention and control of the lipid peroxidation of the membranes. (c) 2008 Elsevier B.V. All rights reserved.