Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
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DOI：
10.1186/s13148-020-00905-6
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发表时间：
2020-07-31
影响因子：
5.7
通讯作者：
Marioni, Riccardo E.
中科院分区：
文献类型：
--
作者：
Hillary, Robert F.;Stevenson, Anna J.;Marioni, Riccardo E.
背景相同年龄的个体表现出不同的生物衰老速度。已经提出了一些衡量生物年龄的措施，这些措施利用了DNA甲基化特征中与年龄相关的变化。这些测量包括五个表观遗传时钟，它们提供了一个指数，表明一个人的生物年龄与他们测量时的实际年龄相差多大。这五个时钟包括基于甲基化的时间顺序年龄(HorvathAge，HannumAge)、全因死亡率(dNaM PhenoAge，dNaM grmage)和端粒长度(dNaM端粒长度)的预测因子。第六个关于衰老的表观遗传学指标与这些时钟的不同之处在于，它充当了一个速度计，提供了一个单一的时间点测量个人生物衰老的速度。这种衡量衰老的指标被称为达尼丁PoAm。在这项研究中，我们测试了这六项关于老龄化的表观遗传学指标与高收入国家(N)疾病负担和死亡率的主要原因的流行率和发病率之间的关系。
Background Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. These measures include five 'epigenetic clocks' which provide an index of how much an individual's biological age differs from their chronological age at the time of measurement. The five clocks encompass methylation-based predictors of chronological age (HorvathAge, HannumAge), all-cause mortality (DNAm PhenoAge, DNAm GrimAge) and telomere length (DNAm Telomere Length). A sixth epigenetic measure of ageing differs from these clocks in that it acts as a speedometer providing a single time-point measurement of the pace of an individual's biological ageing. This measure of ageing is termed DunedinPoAm. In this study, we test the association between these six epigenetic measures of ageing and the prevalence and incidence of the leading causes of disease burden and mortality in high-income countries (n