Relationship between ABO genotype and A antigen expression on platelets
Relationship between ABO genotype and A antigen expression on platelets
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DOI：
10.1111/j.1537-2995.2012.03952.x
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发表时间：
2013-08-01
期刊：
影响因子：
2.9
通讯作者：
Dzik, Walter
中科院分区：
文献类型：
--
作者：
DeLelys, Michelle E.;Ochoa, Gorka;Dzik, Walter
背景：虽然已知血小板（PLT）表达ABH抗原，但与红细胞相比，PLT上的表达程度不同，PLT上ABH表达与基因型之间的关系尚未得到深入研究。研究设计和方法：我们使用荧光标记试剂和流式细胞术检测了100名正常志愿者plt上的血型H和A抗原。个体也使用市售的基因分型系统在ABO位点进行基因分型。结果：A和H抗原在不同个体的plt中表达差异很大。在A组和AB组中，H抗原表达量显著大于A抗原表达量(p
BACKGROUND: Although platelets (PLTs) are known to express ABH antigens, the extent of expression is different on PLTs compared with red blood cells and the relationship between PLT ABH expression and genotype has not been thoroughly investigated.STUDY DESIGN AND METHODS: We measured blood group H and A antigens on PLTs from 100 normal volunteers using fluorescent-conjugated reagents and flow cytometry. Individuals were also genotyped at the ABO locus using a commercially available genotyping system.RESULTS: Expression of A and H antigen varied widely on PLTs from different individuals. Among group A and AB persons, H antigen expression was significantly greater than A antigen (p