Maternal Influence on Child HPA Axis: A Prospective Study of Cortisol Levels in Hair
Maternal Influence on Child HPA Axis: A Prospective Study of Cortisol Levels in Hair
复制标题
DOI：
10.1542/peds.2013-1178
复制
发表时间：
2013-11-01
期刊：
影响因子：
8
通讯作者：
Ludvigsson, Johnny
中科院分区：
文献类型：
--
作者：
Karlen, Jerker;Frostell, Anneli;Ludvigsson, Johnny
目的：调查头发中皮质醇浓度作为幼儿及其母亲长期压力的生物标志物，以及与围产期和社会人口学因素的关系。方法：对瑞典东南部 100 名所有婴儿及其母亲在怀孕期间进行重复测量，进行前瞻性队列研究。通过头发中的皮质醇来评估长期压力水平。调查问卷涵盖了儿童第一年的围产期和社会人口学因素。结果：妊娠中期和晚期的母亲头发皮质醇与婴儿第一年和第三年的头发皮质醇相关。儿童头发中的皮质醇水平随着时间的推移而下降，并与随后的每个年龄相关，即 1 至 3 岁（r = 0.30，P = .002）、3 至 5 岁（r = 0.39，P < .001）以及 5 至 8 岁（r = 0.44，P < .001）。重复测量随时间推移呈现显着的线性关联 (P < .001)。高水平的头发皮质醇与出生体重（beta = .224，P = .020）、不适合胎龄的尺寸（beta = .231，P = .017）以及居住在公寓与房屋（beta = .200，P = .049）之间存在关联。此外，我们发现头发中高水平的皮质醇与心理社会压力暴露相关的其他因素有关。结论：母亲及其孩子的头发皮质醇水平之间的相关性表明孩子的下丘脑-垂体-肾上腺皮质轴具有遗传性特征或母亲校准。皮质醇的输出逐渐稳定，似乎具有稳定的特性。头发中的皮质醇浓度有可能成为长期压力的生物标志物，特别适用于研究压力如何影响儿童健康时作为一种非侵入性方法。
OBJECTIVE: To investigate cortisol concentrations in hair as biomarker of prolonged stress in young children and their mothers and the relation to perinatal and sociodemographic factors.METHODS: Prospective cohort study of 100 All Babies In Southeast Sweden study participants with repeated measures at 1, 3, 5, and 8 years and their mothers during pregnancy. Prolonged stress levels were assessed through cortisol in hair. A questionnaire covered perinatal and sociodemographic factors during the child's first year of life.RESULTS: Maternal hair cortisol during the second and third trimester and child hair cortisol at year 1 and 3 correlated. Child cortisol in hair levels decreased over time and correlated to each succeeding age, between years 1 and 3 (r = 0.30, P = .002), 3 and 5 (r = 0.39, P < .001), and 5 and 8 (r = 0.44, P < .001). Repeated measures gave a significant linear association over time (P < .001). There was an association between high levels of hair cortisol and birth weight (beta = .224, P = .020), nonappropriate size for gestational age (beta = .231, P = .017), and living in an apartment compared with a house (beta = .200, P = .049). In addition, we found high levels of cortisol in hair related to other factors associated with psychosocial stress exposure.CONCLUSIONS: Correlation between hair cortisol levels in mothers and their children suggests a heritable trait or maternal calibration of the child's hypothalamic-pituitary-adrenocortical axis. Cortisol output gradually stabilizes and seems to have a stable trait. Cortisol concentration in hair has the potential to become a biomarker of prolonged stress, especially applicable as a noninvasive method when studying how stress influences children's health.