Cellular senescence and its impact on the circadian clock
Cellular senescence and its impact on the circadian clock
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DOI：
10.1093/jb/mvab115
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发表时间：
2021-10-20
影响因子：
2.7
通讯作者：
Nakahata, Yasukazu
中科院分区：
文献类型：
--
作者：
Ahmed, Rezwana;Reza, Hasan Mahmud;Nakahata, Yasukazu
衰老是慢性非传染性疾病的最大危险因素之一，而细胞衰老是衰老和年龄相关疾病的主要原因之一。晚年衰老细胞的持续存在似乎会以组织特异性方式引起混乱。衰老会扰乱生物钟系统，导致许多与年龄相关的疾病，如代谢综合征、癌症、心脏病和睡眠障碍，以及感染的可能性增加。在这篇综述中，我们首先讨论细胞衰老及其一些基本特征和有害作用。然后，我们讨论了一个相对未被探索的关于细胞衰老和生物钟之间联系的话题，并试图确定细胞衰老是否可能是生物钟破坏的根本因素。
Ageing is one of the greatest risk factors for chronic non-communicable diseases, and cellular senescence is one of the major causes of ageing and age-related diseases. The persistent presence of senescent cells in late life seems to cause disarray in a tissue-specific manner. Ageing disrupts the circadian clock system, which results in the development of many age-related diseases such as metabolic syndrome, cancer, cardiac diseases and sleep disorders and an increased susceptibility to infections. In this review, we first discuss cellular senescence and some of its basic characteristics and detrimental roles. Then, we discuss a relatively unexplored topic on the link between cellular senescence and the circadian clock and attempt to determine whether cellular senescence could be the underlying factor for circadian clock disruption.