Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
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DOI：
10.1038/ni.1693
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发表时间：
2009-03-01
影响因子：
30.5
通讯作者：
Veillette, Andre
中科院分区：
文献类型：
--
作者：
Cruz-Munoz, Mario-Ernesto;Dong, Zhongjun;Veillette, Andre
CRACC是信号淋巴细胞激活分子家族的自关联成员，在免疫系统细胞上表达，包括自然杀伤细胞和活化的T细胞。在这里，我们使用几种互补的方法来研究CRACC的功能和作用机制，包括产生CRACC缺陷小鼠。我们的研究结果表明，CRACC通过依赖于适配器EAT-2而不是相关适配器SAP的机制积极调节自然杀伤细胞的功能。然而，在没有EAT-2的情况下，CRACC有效地抑制自然杀伤细胞的功能。CRACC在T细胞中也有抑制作用，而T细胞通常缺乏EAT-2。因此，CRACC可以根据细胞环境和效应蛋白的可用性对免疫系统细胞施加激活或抑制影响。
CRACC is a self-associating member of the signaling lymphocytic activation molecule family that is expressed on cells of the immune system, including natural killer cells and activated T cells. Here we examine the function and mechanism of action of CRACC using several complementary approaches, including the generation of a CRACC-deficient mouse. Our results demonstrate that CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.