Repair of bone defects in revision hip arthroplasty by implantation of a new bone‐inducing material comprised of recombinant human BMP‐2, Beta‐TCP powder, and a biodegradable polymer: An experimental study in dogs
Repair of bone defects in revision hip arthroplasty by implantation of a new bone‐inducing material comprised of recombinant human BMP‐2, Beta‐TCP powder, and a biodegradable polymer: An experimental study in dogs
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DOI：
10.1002/jor.20424
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发表时间：
2007-08
影响因子：
2.8
通讯作者：
M. Hoshino;T. Namikawa;Minori Kato;H. Terai;Susumu Taguchi;K. Takaoka
中科院分区：
文献类型：
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作者：
M. Hoshino;T. Namikawa;Minori Kato;H. Terai;Susumu Taguchi;K. Takaoka
应用含BMP-2的重组油灰型人工髋关节假体与人工髋关节假体相结合的方法，重建与翻修全髋关节置换术(THA)相似的犬髋关节。取10只犬股骨近端内侧半段和髋臼上段骨伴髂骨内壁穿孔，造成骨缺损。在5只狗的髋关节假体中植入由合成聚合物(聚D，L-乳酸-聚乙二醇嵌段共聚物)、β-磷酸三钙粉末和重组人骨形成蛋白-2组成的油灰材料(骨形态发生蛋白/聚合物/磷酸三钙组)。其余5只犬植入相同材料，不含重组人骨形态发生蛋白-2(对照组)。在骨形态发生蛋白/聚合物/磷酸三钙组，术后4周，股骨和髋臼假体周围的缺损处开始出现新的不透射线阴影。12周时，与假体接触的新骨完全填满了缺损处。组织学上，重组人骨形态发生蛋白-2/聚合物/β-磷酸三钙复合油灰种植体已被完全吸收，并被新骨取代。对照组未见骨缺损修复。这种材料的骨修复能力有效地消除了翻修髋关节时对自体或同种异体来源的骨移植的依赖，从而为需要此类手术的髋关节病例开辟了一种潜在的新治疗方法。©2007矫形外科研究会。由Wiley期刊公司出版，J Orthop Res 25：1042-1051,2007
A recombinant BMP‐2‐retaining putty‐form implant in combination with a hip prosthesis was used to reconstruct a canine hip joint with defects similar to those encountered in revision total hip arthroplasty (THA). The bone defects were made by resecting the medial half of the proximal femur and the superior acetabular bone with inner iliac wall perforation in 10 dogs. In five dogs, hip prostheses were implanted with the putty material consisting of a synthetic polymer (poly D,L‐lactic acid‐polyethylene glycol block copolymer), β‐tricalcium phosphate powder, and recombinant human BMP‐2 in each defect (BMP/Polymer/TCP group). In the remaining five dogs, the same material without rhBMP‐2 (control group) was implanted. In the BMP/Polymer/TCP group, new radiopaque shadows began to appear 4 weeks after surgery at the defects around the hip prostheses on both the femoral and acetabular sides. At 12 weeks, the defects were completely filled with new bone in contact with the prosthesis. On histology, the rhBMP‐2/Polymer/β‐TCP composite putty implants had been completely resorbed and replaced by new bone. Repair of the bone defects was not seen in the control group. The ability of this material to restore bone effectively eliminates the dependency on bone grafts of autogeneic or allogeneic origin for revision hip arthroplasty and thus opens up a potential new treatment approach in hip cases requiring this type of surgery. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1042–1051, 2007