Oxidative stress specifically downregulates survivin to promote breast tumour formation.
Oxidative stress specifically downregulates survivin to promote breast tumour formation.
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DOI：
10.1038/bjc.2013.40
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发表时间：
2013-03-05
影响因子：
8.8
通讯作者：
Singh R
中科院分区：
文献类型：
--
作者：
Pervin S;Tran L;Urman R;Braga M;Parveen M;Li SA;Chaudhuri G;Singh R
Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER−) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, increases aggressive behaviour in ER− breast tumours, oxidative stress (OS) promotes the progression of ER+ breast tumours. Mechanisms and molecular targets by which OS promotes tumourigenesis remain poorly understood. DETA-NONOate, a nitric oxide (NO)-donor induces OS in breast cancer cell lines by early re-localisation and downregulation of cellular survivin. Using in vivo models of HMLEHRAS xenografts and E2-induced breast tumours in ACI rats, we demonstrate that high OS downregulates survivin during initiation of tumourigenesis. Overexpression of survivin in HMLEHRAS cells led to a significant delay in tumour initiation and tumour volume in nude mice. This inverse relationship between survivin and OS was also observed in ER+ human breast tumours. We also demonstrate an upregulation of NADPH oxidase-1 (NOX1) and its activating protein p67, which are novel markers of OS in E2-induced tumours in ACI rats and as well as in ER+ human breast tumours. Our data, therefore, suggest that downregulation of survivin could be an important early event by which OS initiates breast tumour formation.
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影响因子：
3.6
作者：
Desouki, MM;Kulawiec, M;Singh, KK
通讯作者：
Singh, KK
影响因子：
3.6
作者：
Li, Qing-Xia;Zhao, Jing;Yang, An-Gang
通讯作者：
Yang, An-Gang
影响因子：
11.2
作者：
Engels, Knut;Knauer, Shirley K.;Stauber, Roland H.
通讯作者：
Stauber, Roland H.
DOI：
10.1016/j.bbrc.2011.03.039
发表时间：
2011-04-08
影响因子：
3.1
作者：
Oliveras-Ferraros, Cristina;Vazquez-Martin, Alejandro;Menendez, Javier A.
通讯作者：
Menendez, Javier A.
DOI：
10.1158/1078-0432.ccr-10-2743
发表时间：
2011-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Korkaya H;Liu S;Wicha MS
通讯作者：
Wicha MS